CYP4F2

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 19: 15.88 – 15.9 MbChr 8: 72.74 – 72.76 MbPubMed searchWikidata

Cytochrome P450 4F2 (CYP4F2) is a human enzyme belonging to the cytochrome P450 (CYP) superfamily. It regulates inflammation by inactivating leukotriene B₄, a potent inflammatory mediator, and genetic variations in its encoding gene (CYP4F2, part of a cluster of cytochrome P450 genes on chromosome 19) affect the dosing of the anticoagulantwarfarin.

CYP enzymes function primarily as monooxygenases, adding a hydroxy group to their substrates. They are most highly expressed in the liver and are responsible for about 80% of oxidative metabolism and about 50% of the elimination of commonly used drugs in humans.

The primary substrate of CYP4F2 is leukotriene B₄ (LTB4), an eicosanoidinflammatory mediator. By hydroxylating LTB4 to its inactivated form 20-hydroxy-LTB4, the enzyme helps regulate inflammation. CYP4F2 also metabolizes other eicosanoids derived from arachidonic acid in white blood cells.

CYP4F2 also metabolizes certain fatty acids and fat-soluble vitamins, including vitamin E and vitamin K, and bioactivates prodrugs such as pafuramidine. Genetic variations in CYP4F2 affect enzymatic activity, with implications for vitamin K bioavailability and the dosing of vitamin K antagonists like warfarin.