Topic summary
COX-1
Extracted from the Wikipedia article Cyclooxygenase-1.
Clinical significance
COX-1 is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin. Thromboxane A2, the major product of COX-1 in platelets, induces platelet aggregation. The inhibition of COX-1 is sufficient to explain why low dose aspirin is effective at reducing cardiac events.