Topic summary
CFAP298
Cilia- and flagella-associated protein 298 is a proteinencoded by CFAP298 gene. It is of interest in part for its association with various diseases. It has been found in high levels in the bone marrow of patients with a negative prognosis of acute myeloid leukemia and an abnormal karyotype. Male Alzheimer's patients have shown a decrease in expression of CFAP298 in their blood cells. The CFAP298 gene lies within the critical region of Down syndrome. There are no clear paralogs in humans, but the gene has homologues widely conserved among animals, fungi, and algae.