Topic summary
CDK6
Extracted from the Wikipedia article Cyclin-dependent kinase 6.
Mechanisms of regulation
CDK6 is positively regulated primarily by its union to the D cyclins D1, D2 and D3. If this subunit of the complex is not available, CDK6 is not active or available to phosphorylate the Rb substrate. An additional positive activator needed by CDK6 is the phosphorylation in a conserved threonine residue located in 177 position, this phosphorylation is done by the cdk-activating kinases, CAK. Additionally, CDK6 can be phosphorylated and activated by the Kaposi's sarcoma-associated herpesvirus, stimulating the CDK6 over activation and uncontrolled cell proliferation.