BLT2

Pancreatic cancer

BLT2 receptor protein and mRNA was found to be markedly elevated in human advanced pancreatic intraepithelial neoplasias in their primary pancreas sites as well as in lymph nodemetastasis sites; mRNA for BLT1 was also elevated in these tissues but to a ~5-fold greater extent. Both receptors' mRNA were also expressed in a wide range of human pancreas cancer cell lines with BLT1 receptor mRNA ~2-fold greater than that for BLT2. The stable over expression of BLT2 in AsPC-1, Colo357, and PANC-1 human pancreas cancer cell lines increased these cells' in vitro growth rates; specific BLT2 agonists also stimulated Colo367 and Panc-1 cell growth. BLT2 receptors mediated the in vitro migration of Panc-1 cells. These results allow that BLT2 receptors may contribute to the malignant growth and metastasis of human pancreas cancer.