Topic summary
Alloimmune
Extracted from the Wikipedia article Alloimmunity.
T-lymphocytes
Alloimmune response can be enhanced by proinflammatory cytokines and by CD4 T-lymphocytes that are responsible for APC maturation and IL-2 production. IL-2 is crucial for memory CD8 T cell development. These cells may represent a serious problem after the transplantation. As the effect of being exposed to various infections in the past, antigen-specific T-lymphocytes have developed in patient's body. Part of them is kept in organism as memory cells and these cells could be a reason for "cross-reactivity" – immune response against unrelated but similar graft alloantigens. This immune response is called secondary and is faster, more efficient and more robust.