Topic summary
4-HO-DET
4-HO-DET, also known as 4-hydroxy-N,N-diethyltryptamine as well as ethocin or CZ-74, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to psilocin (4-HO-DMT). It is taken orally.
The drug acts as a non-selectiveserotonin receptor agonist, including of the serotonin5-HT2A receptor among others. It produces psychedelic-like effects in animals. 4-HO-DET is closely structurally related to other psychedelic tryptamines such as psilocin, diethyltryptamine (DET), and 4-HO-MET. Ethocybin (4-PO-DET; CEY-19) and 4-AcO-DET are assumed to act as prodrugs of 4-HO-DET.
4-HO-DET was first described in the literature by 1963. It was developed at Sandoz by Albert Hofmann and colleagues. The drug was studied in psychedelic-assisted psychotherapy by Hanscarl Leuner and colleagues in the 1960s. Later, it was described further by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved). 4-HO-DET was encountered as a novel designer drug in 2005.