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Largest known protein in human musclesMore reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 2: 178.53 – 178.83 MbChr 2: 76.7 – 76.98 MbPubMed searchWikidataCardiac sarcomere structure, featuring titinReconstruction of the thin (green) and thick filament from mammalian cardiac tissue.

Protein domainProtein domainSelf-stable region of a protein's chain that folds independently from the restPyruvate kinase, a protein with three domains (PDB: 1PKN​).In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and folds independently from the rest. Each domain forms a compact, folded three-dimensional structure. Many proteins consist of several domains, and a domain may appear in a variety of different proteins.MyofibrilMyofibrilA myofibril (also known as a muscle fibril or sarcostyle) is a basic rod-like organelle of a muscle cell. Skeletal muscles are composed of long, tubular cells known as muscle fibers, and these cells contain many chains of myofibrils. Each myofibril has a diameter of 1–2 micrometres. They are created during embryonic development in a process known as myogenesis.Muscle contractionMuscle contractionMuscle contraction is the activation of tension-generating sites within muscle cells. In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in muscle length (isometric contraction), such as when holding something heavy in the same position. The termination of muscle contraction is followed by muscle relaxation, which is a return of the muscle fibers to their low tension-generating state.ProteinProteinBiomolecule consisting of chains of amino acid residuesA representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acidresidues.Protein foldingProtein foldingProtein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random coil into a more ordered three-dimensional structure. This structure permits the protein to become biologically functional or active. The folding of many proteins begins even during the translation of the polypeptide chain.Striated muscle tissueStriated muscle tissueStriated muscle tissue is a muscle tissue that features repeating functional units called sarcomeres. Under the microscope, sarcomeres are visible along muscle fibers, giving a striated appearance to the tissue. The two types of striated muscle are skeletal muscle and cardiac muscle.MuscleMuscleMuscle is a specialised soft tissue, one of the four basic types of animal tissues. There are three types of muscle tissues in vertebrates: skeletal muscle tissue, cardiac muscle tissue, and smooth muscle tissue. Muscle tissue gives skeletal muscles the ability to contract and relax. Muscle tissue contains special contractile proteins called actin and myosin which interact to cause movement.PeptidePeptidePeptides are short chains of amino acids linked by peptide bonds. A polypeptide is a longer, continuous, unbranched peptide chain. Polypeptides that have a molecular mass of 10,000 Da or more are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. Amino acids comprise peptides as residues.Spring (device)Spring (device)A spring is a device consisting of an elastic but largely rigid material (typically metal) bent or molded into a form (especially a coil) that can return into shape after being compressed, extended or twisted. Springs can store energy when compressed, when extended, and/or when twisted. In everyday use, the term most often refers to coil springs, but there are many different spring designs. Modern springs are typically manufactured from spring steel.GeneGeneIn biology, the word gene has two meanings. The Mendelian gene is a basic unit of . The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of RNA or protein from a gene), DNA is first copied into RNA. RNA can be directly functional or be the intermediate template for the synthesis of a protein.Denaturation (biochemistry)Denaturation (biochemistry)IUPAC definitionProcess of partial or total alteration of the native secondary, and/or tertiary, and/or quaternary structures of proteins or nucleic acids resulting in a loss of bioactivity. Note 1: Modified from the definition given in ref. Note 2: Denaturation can occur when proteins and nucleic acids are subjected to elevated temperature or to extremes of pH, or to nonphysiological concentrations of salt, organic solvents, urea, or other chemical agents.MicrometreMicrometreThe micrometre (micrometer in US spelling; symbol: μm) is a unit of length in the International System of Units (SI) equalling 10 metre (SI standard prefix "micro-" = 10); that is, one millionth of a metre (or one thousandth of a millimetre, 0.001 mm, or about 0.00004inch). It is also known as the micron.sallimussallimusRelated word or term.Appendix:List of protologisms/Long words/TitinAppendix:List of protologisms/Long words/TitinRelated word or term.

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