Silyl etherSilyl ethers are a group of chemical compounds which contain a silicon atom covalently bonded to an alkoxy group. The general structure is RRRSi−O−R where R is an alkyl group or an aryl group. Silyl ethers are usually used as protecting groups for alcohols in organic synthesis.Silyl enol etherIn organosilicon chemistry, silyl enol ethers are a class of organic compounds that share the common functional group R3Si−O−CR=CR2, composed of an enolate (R3C−O−R) bonded to a silane (SiR4) through its oxygen end and an ethene group (R2C=CR2) as its carbon end. They are important intermediates in organic synthesis.
SN2 reactionThe bimolecular nucleophilic substitution (SN2) is a type of reaction mechanism that is common in organic chemistry. In the SN2 reaction, a strong nucleophile forms a new bond to an sp-hybridised carbon atom via a backside attack, all while the leaving group detaches from the reaction center in a concerted (i.e. simultaneous) fashion.
SilanizationSilanization is the attachment of an organosilyl group to some chemical species. Almost always, silanization is the conversion of a silanol-terminated surface to an alkylsiloxy-terminated surface. This conversion confers hydrophobicity to a previously hydrophilic surface. This process is often used to modify the surface properties of glass, silicon, alumina, quartz, and metal oxide substrates, which all have an abundance of hydroxyl groups.
Bis(trimethylsilyl)acetamideBis(trimethylsilyl)acetamide (BSA) is an organosilicon compound with the formula MeC(OSiMe3)NSiMe3 (Me = CH3). It is a colorless liquid that is soluble in diverse organic solvents, but reacts rapidly with moisture and solvents containing OH and NH groups. It is used in analytical chemistry to increase the volatility of analytes, e.g., for gas chromatography. It is also used to introduce the trimethylsilylprotecting group in organic synthesis.
Tetra-n-butylammonium fluorideTetra-n-butylammonium fluoride, commonly abbreviated to TBAF and n-Bu4NF, is a quaternary ammonium salt with the chemical formula (CH3CH2CH2CH2)4N+F−. It is commercially available as the white solid trihydrate and as a solution in tetrahydrofuran. TBAF is used as a source of fluoride ion in organic solvents.
Organosilicon chemistryOrganosilicon chemistry is the study of organometallic compounds containing carbon–siliconbonds, to which they are called organosilicon compounds. Most organosilicon compounds are similar to the ordinary organic compounds, being colourless, flammable, hydrophobic, and stable to air. However, silicon carbide is considered an inorganic compound. HistoryIn 1863, Charles Friedel and James Crafts made the first organochlorosilane compound.
Coordination complexA coordination complex is a chemical compound consisting of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of boundmolecules or ions, that are in turn known as ligands or complexing agents. Many metal-containing compounds, especially those that include transition metals (elements like titanium that belong to the periodic table's d-block), are coordination complexes.
EnolateIn organic chemistry, enolates are the organic anions derived from the deprotonation of carbonyl (RR'C=O) compounds. Rarely isolated, they are widely used as reagents in the synthesis of organic compounds. Bonding and structureEnolate anions are electronically related to allyl anions. The anionic charge is delocalized over the oxygen and the two carbon sites. Thus they have the character of both an alkoxide and a carbanion.
Mass spectrometryAnalytical technique based on determining mass to charge ratio of ionsMass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a mass spectrum, a plot of intensity as a function of the mass-to-charge ratio.
Gas chromatographyGas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition. Typical uses of GC include testing the purity of a particular substance or separating the different components of a mixture. In preparative chromatography, GC can be used to prepare pure compounds from a mixture.
Fragmentation (mass spectrometry)In mass spectrometry, fragmentation is the dissociation of energetically unstable molecular ions formed from passing the molecules mass spectrum. These reactions are well documented over the decades and fragmentation patterns are useful to determine the molar weight and structural information of unknown molecules.*As an Amazon Associate I earn from qualifying purchases.