Dose–response relationshipThe dose–response relationship, or exposure–response relationship describes the magnitude of the response of a biochemical or cell-based assay or an organism, as a function of exposure (or doses) to a stimulus or stressor (usually a chemical) after a certain exposure time. Dose–response relationships can be described by dose–response curves, or concentration-response curves. This is explained further in the following sections.
Linear no-threshold modelThe linear no-threshold model (LNT) is a dose-response model used in radiation protection to estimate stochastic health effects such as radiation-induced cancer, genetic mutations and teratogenic effects on the human body due to exposure to ionizing radiation. The model assumes a linear relationship between dose and health effects, even for very low doses where biological effects are more difficult to observe.
Oxygen toxicityOxygen toxicity is a condition resulting from the harmful effects of breathing molecular oxygen (O2) at increased partial pressures. Severe cases can result in cell damage and death, with effects most often seen in the central nervous system, lungs, and eyes.
ToxicologyToxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology.
Greek languageIndo-European languageGreek (Modern Greek: ελληνικά, romanized: elliniká; Ancient Greek: ἑλληνική, romanized: hellēnikḗ) is an Indo-European language, constituting an independent Hellenic branch within the Indo-European language family.
PhysiologyPhysiology (; from Ancient Greek (phúsis)'nature, origin' and (-logía)'study of') is the scientific study of functions and mechanisms in a living system. As a subdiscipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out chemical and physical functions in a living system.
StressorSomething that causes stress to an organism A stressor is a chemical or biological agent, environmental condition, external stimulus or an event seen as causing stress to an organism. Psychologically speaking, a stressor can be events or environments that individuals might consider demanding, challenging, and/or threatening individual safety.
OxygenChemical element with atomic number 8 (O)–↑O↓Snitrogen ← oxygen → fluorineRespiration (physiology)In physiology, respiration is a biological process that facilitates the transport of oxygen from the outside environment to bodily tissues and the removal of carbon dioxide of an organism using a respiratory system. The physiological definition of respiration differs from the biological definition of cellular respiration, which is a metabolic process by which an organism obtains energy (in the form of ATP and NADPH) by oxidizing nutrients and releasing waste products.
PharmacologyPharmacology is the science of drugs and medications, including a substance's origin, composition and interaction with biological systems; specifically through pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. The discipline examines these interactions through pharmacokinetics (what the body does to the drug) and pharmacodynamics (what the drug does to the body), both of which determine how a substance alters normal or abnormal biochemical function.
Therapeutic indexThe therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose. It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect.XenobioticA xenobiotic is a chemical substance found within an organism that is not naturally produced or expected to be present within the organism. It can also cover substances that are present in much higher concentrations than are usual.*As an Amazon Associate I earn from qualifying purchases.