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Genentech

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Genentech, Inc. is an American biotechnologycorporation headquartered in South San Francisco, California. It operates as an independent subsidiary of holding company Roche. Genentech Research and Early Development operates as an independent center within Roche. Historically, the company is regarded as the world's first biotechnology company. As of 2026, Genentech employs around 12,100 people. HistoryThe company was founded in 1976 by venture capitalist Robert A. Swanson and biochemist Herbert Boyer.

University of California, San FranciscoUniversity of California, San FranciscoPublic university in California, USThe University of California, San Francisco (UCSF or UC San Francisco) is a publicland-grantresearch university in San Francisco, California, United States. It is part of the University of California system and is dedicated entirely to health science and life science. It conducts research and teaching in medical and biological sciences. UCSF was founded as Toland Medical College in 1864.South San Francisco, CaliforniaSouth San Francisco, CaliforniaCity in California, United StatesSouth San Francisco is a city in San Mateo County, California, United States, on the San Francisco Peninsula in the San Francisco Bay Area. The city is colloquially termed "South City". The population was 66,105 as of the 2020 census, and was estimated at 64,941 in 2025. HistoryParts of what is now South San Francisco have been populated for more than 5,000 years.RocheRocheF. Hoffmann-La Roche AG, commonly known as Roche (), is a Swiss multinational holding healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the fifth-largest pharmaceutical company in the world by revenue and the leading provider of cancer treatments globally.Drug discoveryDrug discoveryIn the fields of medicine, biotechnology, and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin.BiotechnologyBiotechnologyField of science that uses cells for the creation of productsA biologist conducting research in a biotechnology laboratoryBiotechnology is a multidisciplinary field that involves the integration of natural sciences and engineering sciences to achieve the application of organisms and parts thereof for products and services. The term biotechnology was first used by Károly Ereky in 1919 to refer to the production of products from raw materials with the aid of living organisms.AtezolizumabAtezolizumabAtezolizumab, sold under the brand name Tecentriq among others, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), hepatocellular carcinoma and alveolar soft part sarcoma, but discontinued for use in triple-negative breast cancer (TNBC). It is a fully humanized, engineered monoclonal antibody of IgG1isotype against the protein programmed cell death-ligand 1 (PD-L1).ObinutuzumabObinutuzumabObinutuzumab, sold under the brand name Gazyva among others, is a humanized anti-CD20monoclonal antibody used as a treatment for cancer and active lupus nephritis. It was originated by GlycArt Biotechnology AG and developed by Roche.InsulinInsulinInsulin ( ; from Latin insula 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (INS) gene. It is the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats, and protein by promoting the absorption of glucose from the blood into cells of the liver, fat, and skeletal muscles.Checkpoint inhibitorCheckpoint inhibitor therapy is a form of cancerimmunotherapy. The therapy targets immune checkpoints, key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus. Some cancers can protect themselves from attack by stimulating immune checkpoint targets. Checkpoint therapy can block inhibitory checkpoints, restoring immune system function.SubsidiaryA subsidiary, subsidiary company, or daughter company is a company completely or partially owned or controlled by another company, called the parent company or holding company, which has legal and financial control over the subsidiary company.CorporationCorporationA corporation or body corporate is an individual or other entity such as a company that has been authorized by the state to act as a single entity (a legal entity recognized by private and public law as "born out of statute"; a legal person in a legal context) and recognized as such in law for certain purposes. Early incorporated entities were established by charter (i.e., by an ad hoc act granted by a monarch or passed by a parliament or legislature).

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