Peripheral artery diseasePeripheral artery disease (PAD) is a vascular disorder that causes abnormal narrowing of arteries other than those that supply the heart or brain. PAD can happen in any blood vessel, but it is more common in the legs than the arms. When narrowing occurs in the heart, it is called coronary artery disease (CAD), and in the brain, it is called cerebrovascular disease.
IschemiaIschemiaorischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body. A shortage of blood supply at any site causes a shortage of oxygen (hypoxia) available for cellular metabolism, (i.e., needed to keep tissue alive). Typically, ischemia is caused by problems with blood vessels and the resultant damage to or dysfunction of tissue—e.g., general hypoxia and microvascular dysfunction.
SepsisLife-threatening response to infectionMedical conditionSepsis, also known as septicemia (or septicaemia in British English) is a potentially life-threatening condition that arises when the body's dysregulated response to infection causes injury to its own tissues and organs. This initial stage of sepsis is followed by dysregulation of the immune system. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.
NecrosisNecrosis (from Ancient Greek (nékrōsis)'death') is a form of cell injury which results in the premature death of cells in living tissue by autolysis. The term "necrosis" came about in the mid-19th century and is commonly attributed to German pathologist Rudolf Virchow, who is often regarded as one of the founders of modern pathology.
FrostbiteFrostbite is an injury to skin or other living tissue that is allowed to freeze, especially affecting the fingers, toes, nose, ears, cheeks and chin. Most often, frostbite occurs in the hands and feet, often preceded by frostnip, a paling or reddening of a body part as its blood vessels constrict that tingles, feels very cold, or simply feels numb. This may be followed by the clumsiness and white or bluish, waxy-looking skin that evidence full-blown frostbite.
DiabetesGroup of endocrine diseases characterized by high blood sugar levelsMedical conditionDiabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes tends to progress in severity, and is due to either a reduced production of the hormone insulin by the pancreas or unresponsiveness of bodily cells to insulin's effects.
FeverFever or pyrexia in humans is a symptom of an anti-infection defense mechanism that appears with body temperature exceeding the normal range caused by an increase in the body's temperature set point in the hypothalamus. There is no single agreed-upon upper limit for normal temperature: sources use values ranging between 37.2 and 38.3 °C (99.0 and 100.9 °F) in humans. The increase in set-point triggers increased muscle contractions and causes a feeling of cold or chills.
HIV/AIDSThe human immunodeficiency virus (HIV) is a retrovirus that attacks the immune system. Without treatment, it can lead to a spectrum of conditions including acquired immunodeficiency syndrome (AIDS). It is a preventable disease. It can be managed with treatment and become a manageable chronic health condition.
InfluenzaInfectious diseaseMedical conditionInfluenza, commonly known as the flu, is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin one to four (typically two) days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children.
Major traumaMajor trauma is any injury that has the potential to cause prolonged disability or death. There are many causes of major trauma, blunt and penetrating, including falls, motor vehicle collisions, stabbing wounds, and gunshot wounds. Depending on the severity of injury, quickness of management, and transportation to an appropriate medical facility (called a trauma center) may be necessary to prevent loss of life or limb.
AlcoholismAlcoholism is the continued drinking of alcohol despite the user being unable to manage the problems it causes. Some definitions require evidence of dependence and withdrawal. Problematic alcohol use has been mentioned in the earliest historical records. The World Health Organization (WHO) estimated there were 283 million people with alcohol use disorders worldwide as of 2016.
SmokingSmoking is the combustion of a substance, usually plant material, and the inhalation of resulting fumes. Today, smoking is mostly practiced by rolling the dried leaves of the tobacco plant into a cigarette. Other forms of tobacco smoking include the use of a smoking tobacco with a pipe or cigar, or using a bong. Cigarette smokers almost always inhale the smoke; most pipe and cigar smokers do not inhale.
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