Ena/Vasp homology proteinsENA/VASP homology proteins or EVH proteins are a family of closely related proteins involved in cell motility in vertebrate and invertebrate animals. EVH proteins are modular proteins that are involved in actin polymerization, as well as interactions with other proteins. Within the cell, ENA/VASP proteins are found at the leading edge of lamellipodia and at the tips of filopodia.
PseudopodiaA pseudopod or pseudopodium (pl.: pseudopods or pseudopodia) is a temporary arm-like projection of a eukaryoticcell membrane that is emerged in the direction of movement. Filled with cytoplasm, pseudopodia primarily consist of actin filaments and may also contain microtubules and intermediate filaments. Pseudopods are used for motility and ingestion. They are often found in amoebas. Different types of pseudopodia can be classified by their distinct appearances.
FascinFascin is an actin bundling protein. Species and tissue distributionIt is a 54–58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates, including humans. Fascin (from the Latin for bundle) is spaced at 11 nanometre intervals along the filament.
FimbrinMore reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 3: 142.6 – 142.71 MbChr 9: 95.63 – 95.73 MbPubMed searchWikidataFimbrin also known as is plastin 1 is a protein that in humans is encoded by the PLS1 gene. Fimbrin is an actin cross-linking protein important in the formation of filopodia. StructureFimbrin belongs to the calponinhomology (CH) domain superfamily of actin cross-linking proteins.
Cell migrationCell migration is the movement of cells, either individually or as a group. It is a central process in the development and maintenance of multicellular organisms: tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations. Cells often migrate in response to specific external signals, including chemical signals and mechanical signals.
Rho family of GTPasesThe Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA.
Actin filamentActin filaments (also known as microfilaments) are protein filaments in the cytoplasm of eukaryoticcells that form part of the cytoskeleton. They are primarily composed of polymers of actin, but are modified by and interact with numerous other proteins in the cell. Actin filaments are usually about 7 nm in diameter and made up of two strands of actin.LamellipodiumThe lamellipodium (pl.: lamellipodia) (from Latinlamella, related to , "thin sheet", and the Greek radical pod-, "foot") is a cytoskeletalprotein actin projection on the leading edge of the cell. It contains a quasi-two-dimensional actin mesh (The overall shape is a flat sheet, but if you zoom into the mesh itself, the individual ropes occasionally hop over each other in 3D space); the whole structure propels the cell across a substrate.
PolymerizationIn polymer chemistry, polymerization (American English), or polymerisation (British English), is a process of reacting monomer molecules together in a chemical reaction to form polymer chains or three-dimensional networks. There are many forms of polymerization and different systems exist to categorize them.
Cell (biology)Basic unit of life formsThe cell is the basic structural and functional unit of all forms of life or organisms. The term comes from the Latin word cellula meaning 'small room'. A biological cell basically consists of a semipermeablecell membrane enclosing cytoplasm that contains genetic material. Most cells are only visible under a microscope.
CDC42Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division, and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.*As an Amazon Associate I earn from qualifying purchases.