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Epidermis

The epidermis is the outermost of the three major layers that constitute the skin, the inner layers being the dermis and hypodermis. The epidermal layer provides a barrier to infection from environmental pathogens and regulates the amount of water released from the body into the atmosphere through transepidermal water loss. The epidermis is composed of multiple layers of flattened cells that overlie a base layer (stratum basale) composed of perpendicular columnar cells.

Stratum basaleStratum basaleThe stratum basale (basal layer, sometimes referred to as stratum germinativum) is the deepest layer of the five layers of the epidermis, the external covering of skin in mammals. The stratum basale is a single layer of columnar or cuboidalbasal cells. The cells are attached to each other and to the overlying stratum spinosum cells by desmosomes and hemidesmosomes. The nucleus is large, ovoid and occupies most of the cell.Stratified squamous epitheliumStratified squamous epitheliumA stratified squamous epithelium consists of squamous (flattened) epithelial cells arranged in layers upon a basal membrane. Only one layer is in contact with the basement membrane; the other layers adhere to one another to maintain structural integrity. Although this epithelium is referred to as squamous, many cells within the layers may not be flattened; this is due to the convention of naming epithelia according to the cell type at the surface.EpitheliumEpitheliumEpithelium or epithelial tissue is a thin, continuous, protective layer of cells with little extracellular matrix. An example is the epidermis, the outermost layer of the skin. Epithelial (mesothelial) tissues line the outer surfaces of many internal organs, the corresponding inner surfaces of body cavities, and the inner surfaces of blood vessels. Epithelial tissue is one of the four basic types of animaltissue, along with connective tissue, muscle tissue and nervous tissue.Transepidermal water lossTransepidermal water lossTransepidermal water loss (TEWL or TWL) is the loss of water that passes from inside a body (animal or plant) through the epidermis (that is, either the epidermal layer of animal skin or the epidermal layer of plants) to the surrounding atmosphere via diffusion and evaporation processes. TEWL in mammals is also known as insensible water loss (IWL), as it is a process over which organisms have little physiologic control and of which they are usually mostly unaware.SkinSkinSkin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation. Other animal coverings, such as the arthropod exoskeleton, have different developmental origin, structure and chemical composition. The adjective cutaneous means "of the skin" (from Latin cutis 'skin').DermisDermisThe dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain. It is divided into two layers, the superficial area adjacent to the epidermis called the papillary region and a deep thicker area known as the reticular dermis. The dermis is tightly connected to the epidermis through a basement membrane.Subcutaneous tissueSubcutaneous tissueThe subcutaneous tissue (from Latin subcutaneous'beneath the skin'), also called the hypodermis, hypoderm (from Greek'beneath the skin'), subcutis, or superficial fascia, is the lowermost layer of the integumentary system in vertebrates. The types of cells found in the layer are fibroblasts, adipose cells, and macrophages. The subcutaneous tissue is derived from the mesoderm, but unlike the dermis, it is not derived from the mesoderm's dermatome region.Stem cellStem cellUnspecialized biological cell that can become specializedIn multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each.AtmosphereAtmosphereAn atmosphere is a layer of gases that envelop an astronomical object, held in place by the gravity of the object. The name originates from Ancient Greek (atmós)'vapour, steam' and (sphaîra)'sphere'. An object acquires most of its atmosphere during its primordial epoch, either by accretion of matter or by outgassing of volatiles.InfectionInfectionInvasion of an organism's body by pathogenic agentsMedical conditionAn infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease is an illness resulting from an infection, and some infectious diseases are also communicable (transmissible). Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses.PenisPenisPrimary sexual organ of male animalsIn many animals, a penis (; pl.: penises or penes) is the male sexual organ used to inseminate females (or hermaphrodites) during copulation. Such organs occur in both vertebrates and invertebrates, but males do not bear a penis in every animal species. Furthermore, penises are not necessarily homologous. The term penis applies to many intromittent organs, but not to all.Sole (foot)Sole (foot)In humans, the sole of the foot is anatomically referred to as the plantar aspect.

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