List of largest biomedical companies by revenueThe following is a list of independent pharmaceutical, biotechnology and medical companies listed on a stock exchange (as indicated) that have generated a revenue of at least US$10 billion, ranked by their revenue in the respective financial year. It does not include biotechnology companies that are now owned by, or form a part of, larger pharmaceutical groups.
DenosumabDenosumab, sold under the brand names Prolia and Xgeva among others, is a human monoclonal antibody used for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. The most common side effects are joint and muscle pain in the arms or legs. Denosumab is a human IgG2 monoclonal antibody that inhibits the protein RANKL (receptor activator of nuclear factor kappa-Β ligand).
ApremilastApremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). It is taken by mouth.
BiopharmaceuticalA biopharmaceutical, also known as a biological medical product, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, they include vaccines, whole blood, blood components, allergenics, somatic cells, gene therapies, tissues, recombinant therapeutic protein, monoclonal antibodies, and living medicines used in cell therapy.EvolocumabEvolocumab, sold under the brand name Repatha, is a monoclonal antibody drug. It is an immunotherapy medication for the treatment of hyperlipidemia. Evolocumab inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a protein that targets LDL receptors for degradation; its inhibition enhances the liver's ability to remove LDL-C, the "bad" cholesterol, from the blood.
OsteoporosisOsteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in fracture risk. Bones undergo continuous remodeling: osteoclasts resorb old bone, and osteoblasts synthesize new bone. With advancing age, the rate of resorption exceeds that of bone formation, causing bones to lose density and become more susceptible to fractures.
PsoriasisPsoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete body coverage. Injury to the skin can trigger psoriatic skin changes at that spot, which is known as the Koebner phenomenon. The five main types of psoriasis are plaque, guttate, inverse, pustular, and erythrodermic.
Psoriatic arthritisPsoriatic arthritis (PsA) is a chronic inflammatory arthritis. The classic features of psoriatic arthritis include enthesitis (inflammation of the entheses), synovitis (inflammation of the joint membrane), and dactylitis (sausage-like swelling of the fingers). It particularly affects the peripheral joints, the spine, and the sacroiliac joints.
CorporationA corporation or body corporate is an individual or other entity such as a company that has been authorized by the state to act as a single entity (a legal entity recognized by private and public law as "born out of statute"; a legal person in a legal context) and recognized as such in law for certain purposes. Early incorporated entities were established by charter (i.e., by an ad hoc act granted by a monarch or passed by a parliament or legislature).
HyperlipidemiaHyperlipidemia is abnormally high levels of any or all lipids (e.g. fats, triglycerides, cholesterol, phospholipids) or lipoproteins in the blood. The term hyperlipidemia refers to the laboratory finding itself and is also used as an umbrella term covering any of various acquired or genetic disorders that result in that finding. Hyperlipidemia represents a subset of dyslipidemia and a superset of hypercholesterolemia.
Thousand Oaks, CaliforniaThousand Oaks is the second-largest city in Ventura County, California, located in the northwestern part of Greater Los Angeles. Approximately 15 miles (24 km) from the city of Los Angeles and 40 miles (64 km) from Downtown Los Angeles, it is named after the many oak trees present in the area. The city forms the central populated core of the Conejo Valley. Thousand Oaks was incorporated in 1964 and has since expanded to the west and east.
PortmanteauIn literature, a portmanteau, also known in linguistics and lexicography as a blend word, lexical blend, or simply a blend, is a word formed by combining the meanings and parts of the sounds of two or more words. English examples include smog, coined by blending smoke and fog, and motel, from motor (motorist) and hotel.*As an Amazon Associate I earn from qualifying purchases.