Sushi domain is an evolutionarily conserved

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist o ...

. It is also known as

Complement control protein Complement control protein are proteins that interact with components of the complement system. The complement system is tightly regulated by a network of proteins known as "regulators of complement activation (RCA)" that help distinguish target ...

(CCP) modules or short consensus repeats (SCR). The name derives from the visual similarity of the domain to

nigiri sushi is a Japanese dish of prepared , usually with some sugar and salt, accompanied by a variety of , such as seafood, often raw, and vegetables. Styles of sushi and its presentation vary widely, but the one key ingredient is "sushi rice," also ...

when the

primary structure Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthes ...

is drawn showing the loops created by the

disulfide In biochemistry, a disulfide (or disulphide in British English) refers to a functional group with the structure . The linkage is also called an SS-bond or sometimes a disulfide bridge and is usually derived by the coupling of two thiol groups. In ...

bonds. Sushi domains exist in a wide variety of complement and adhesion proteins. The structure is known for this domain; it is based on a

beta-sandwich Beta-sandwich, β-sandwich domains consisting of 80 to 350 amino acids occur commonly in proteins. They are characterized by two opposing antiparallel beta sheets (β-sheets). The number of strands found in such domains may differ from one protein ...

arrangement - one face made up of three

β-strand The beta sheet, (β-sheet) (also β-pleated sheet) is a common motif of the regular protein secondary structure. Beta sheets consist of beta strands (β-strands) connected laterally by at least two or three backbone hydrogen bonds, forming a gen ...

hydrogen-bond In chemistry, a hydrogen bond (or H-bond) is a primarily electrostatic force of attraction between a hydrogen (H) atom which is covalently bound to a more electronegative "donor" atom or group (Dn), and another electronegative atom bearing a l ...

ed to form a triple-stranded region at its centre, and the other face formed from two separate β-strands. CD21 (also called C3d receptor, CR2,

Epstein Barr virus The surname Epstein ( yi, עפּשטײן, Epshteyn) is one of the oldest Ashkenazi Jewish family names. It is probably derived from the German town of Eppstein, in Hesse; the place-name was probably derived from Gaulish ''apa'' ("water", in the sen ...

receptor or EBV-R) is the receptor for EBV and for C3d, C3dg and iC3b. Complement components may activate

B cells B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or ...

through CD21. CD21 is part of a large signal-transduction complex that also involves CD19, CD81, and Leu13. Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates attached to lipids or proteins. Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a), Dr(a), Es(a), Tc(a/b/c), Wd(a), WES(a/b), IFC and UMC antigens. Complement receptor type 1 (C3b/C4b receptor) (Antigen CD35) belongs to the Knops blood group system and is associated with Kn(a/b), McC(a), Sl(a) and Yk(a) antigens.

Subfamilies

Selectin The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminu ...

s ** CD62E **

CD62L L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in the human by the ''SELL'' gene. L-selectin belongs to the selectin family of proteins, which recognize ...

** CD62P

Examples

Human genes encoding proteins containing this domain include: * AGC1, APOH, *

BCAN Brevican core protein is a protein that in humans is encoded by the ''BCAN'' gene. Brevican is a member of the lectican protein family. Brevican is localised to the surface of neurons in the brain. In melanocytic cells, BCAN gene expression ...

, BF, *

C1R Complement C1r subcomponent (, ''activated complement C1r'', ''C overbar 1r esterase'', ''C1r'') is a protein involved in the complement system of the innate immune system. In humans, C1r is encoded by the ''C1R'' gene. C1r along with C1q and C ...

C1S Complement component 1s (, '' C1 esterase'', ''activated complement C1s'', ''complement C overbar 1r'', ''C1s'') is a protein involved in the complement system The complement system, also known as complement cascade, is a part of the immune s ...

, C2, C4BPA, C4BPB, C6, C7,

CD46 CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the ''CD46'' gene. CD46 is an inhibitory complement receptor. Gene This gene is fou ...

CD55 Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the ''CD55'' gene. DAF regulates the complement system on the cell surface. It recognizes C4b and C3b fragments that are created during ...

, CFB, CFH, CFHR1, CFHR2, CFHR3, CFHR4,

CFHR5 Complement factor H-related protein 5 is a protein that in humans is encoded by the ''CFHR5'' gene. Function CFHR5 is structurally related to complement factor H which plays an important role in the regulation of a branch of the innate immune sy ...

, CR1, CR1L, CR2,

CSMD1 CSMD1 CUB and Sushi multiple domains 1 is a protein that in humans is encoded by the ''CSMD1'' gene. Structure CSMD1 contains 14 N-terminal CUB domains that are separated from each other by a Sushi domains followed by an additional 15 tandem ...

CSMD2 CUB and sushi domain-containing protein 2 is a protein that in humans is encoded by the ''CSMD2'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ...

, CSMD3,

CSPG3 Neurocan core protein is a protein that in humans is encoded by the ''NCAN'' gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thoug ...

, *

DAF Daf ( fa, دف) also known as Dâyere and Riq is a Middle Eastern (mainly Iranian) frame drum musical instrument, used in popular and classical music in South and Central Asia. It is also used in Afghanistan, Azerbaijan, Tajikistan, Iran ...

, *

F13B Coagulation factor XIII B chain is a protein that in humans is encoded by the ''F13B'' gene. This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Pl ...

, FHR4,

GABBR1 Gamma-aminobutyric acid B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the ''GABBR1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of hered ...

, * HP, *

IL2RA Interleukin-2 receptor alpha chain (also called CD25) is the human protein encoded by the ''IL2RA'' gene. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-a ...

, * KIAA0247, * MASP1, MASP2, * PAPPA, PAPPA2, psk-3, *

RAMP An inclined plane, also known as a ramp, is a flat supporting surface tilted at an angle from the vertical direction, with one end higher than the other, used as an aid for raising or lowering a load. The inclined plane is one of the six clas ...

, * SEL-OB,

SELE Sele may refer to: Places Africa * Sele, Burkina Faso, a village in the Ouéleni Department of Burkina Fase. * Sele, Ethiopia, a town in Agbe municipality Asia * Sele, Turkey, a Turkish village in Kailar in Ottoman times *Şələ, Azerbaijan *Se ...

SELL Sell can refer to: People * Brenda Sell (born 1955), American martial arts instructor and highest ranking non-Korean female practitioner of taekwondo * Brian Sell (born 1978), American retired long-distance runner * Edward Sell (priest) (1839� ...

SELP P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and ...

SEZ6 Seizure protein 6 homolog is a protein that in humans is encoded by the ''SEZ6'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

SEZ6L Seizure 6-like protein is a protein that in humans is encoded by the ''SEZ6L'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ' ...

SEZ6L2 Seizure 6-like protein is a protein that in humans is encoded by the ''SEZ6L'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ' ...

SNED1 SNED1 (Sushi, Nidogen, and EGF-like Domains) is an extracellular matrix (ECM) protein expressed at low levels in a wide range of tissues. The gene encodinSNED1is located in the human chromosome 2 at locus q37.3. The corresponding mRNA isolated from ...

, SRPX, SRPX2, SUSD1,

SUSD2 SUSD may refer to: *Safford Unified School District, a school district in Safford, Arizona *Sanders Unified School District, a school district in Apache County, Arizona *Saratoga Union School District, a school district in Saratoga, California *Sau ...

, SUSD4, SVEP1,

, * TAOK1, TPO, VCAN

References

{{InterPro content, IPR000436 Protein domains Single-pass transmembrane proteins