Satoshi Ōmura

is a Japanese biochemist. He is known for the discovery and development of hundreds of pharmaceuticals originally occurring in microorganisms. In 2015, he was awarded the Nobel Prize in Physiology or Medicine jointly with William C. Campbell for their role in the discovery of avermectins and ivermectin, the world's first endectocide and a safe and highly effective microfilaricide. It is believed that the large molecular size of ivermectin prevents it from crossing the blood/aqueous humour barrier, and renders the drug an important treatment of helminthically-derived blindness.

Early life and education

Satoshi Ōmura was born in Nirasaki, Yamanashi Japan in 1935, the second son of Ōmura family. After graduating from the University of Yamanashi in 1958, he was appointed to science teacher at Tokyo Metropolitan Sumida Tech High School. In 1960, he became an auditor of Koji Nakanishi’s course at Tokyo University of Education, one year later, he enrolled in the Tokyo University of Science (TUS) and studied sciences. Ōmura received his M.S. degree from TUS and his Ph.D. in Pharmaceutical Sciences from the University of Tokyo (1968, a Dissertation PhD) and a Ph.D. in Chemistry at TUS (1970).

Career

Since 1965 Ōmura served at Kitasato Institute system.大村智北里研究所顧問・北里大学名誉教授が文化功労者に
北里大学 2012年11月1日 From 1970 to 1990, he also became a part-time lecturer at Tokyo University of Science.

In 1971 while he was a visiting professor at Wesleyan University, he consulted the chairman of the American Chemical Society, Max Tishler, at an international conference. Together they successfully acquired research expenses from Merck & Co.「人間発見」日本経済新聞2010年7月14日 Ōmura was considering continuing his research in the United States, but ultimately he decided to return to Japan.

In 1973, he became a director of the antibiotic laboratory at Kitasato University, and he also started collaborative research with Merck & Co.「 新しい微生物創薬の世界を切り開く 」
JT

In 1975, he became professor of Kitasato University School of Pharmacy. Meanwhile, the Ōmura laboratory raised many researchers and produced 31 university professors and 120 doctors.

At present date, Ōmura is professor emeritus at Kitasato University and Max Tishler Professor of Chemistry at Wesleyan University.

Research

Satoshi Ōmura is known for the discovery and development of various pharmaceuticals originally occurring in microorganisms. He was awarded the 2015 Nobel Prize in Physiology or Medicine jointly with William C. Campbell for discoveries concerning a novel therapy against infections caused by roundworm parasites. More precisely, his research group isolated a strain of '' Streptomyces avermitilis'' that produce the anti-parasitical compound avermectin. Campbell later acquired these bacteria and developed the derived drug ivermectin that was first commercialised for veterinary use in 1981 later put to human use against Onchocerciasis in 1987–88 with the name Mectizan, and is today used against river blindness, lymphatic filariasis, scabies, other parasitic infections.Press release
NobelPrize.org

Since the 1970s, Ōmura has discovered more than 480 new compounds, of which 25 kinds of drugs and reagents are in use. Examples include andrastin, herbimycin, neoxaline as well as:
*a specific inhibitor of protein kinase named staurosporine;
*a proteasome inhibitor named lactacystin;
*a fatty acid biosynthesis inhibitor named cerulenin;

Furthermore, compounds having a unique structure and biological activity discovered by Omura are drawing attention in drug discovery research, and new anticancer drugs and the like have been created.

Selected publications

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Social role

Ōmura served as deputy director and director at the Kitasato Institute. He was devoted to rebuild the laboratory and promoting the establishment of the medical center that is no
Kitasato University Medical Center
Meanwhile, he established a path to rebuilding of the corporate school juridical person, which has integrated with the School corporation Kitasato Gakuen. He succeeded in establishing a new "School corporation Kitasato Institute". In addition, he served as president of the School corporation Joshibi University of Art and Design twice, and served as the honorary school chief of the School corporation Kaichi Gakuen. In 2007, he established th
Nirasaki Omura Art Museum
on his collection.

Awards and honors

A Children's statues leading to adults of onchocerciasis before Kitasato University buildings were produced by sculptors of Burkina Faso in honor of Ōmura's contributions of avermectin and ivermectin, a symbol of the campaign to eradicate onchocerciasis. Similar life-sized bronze statues were erected in World Health Organization (WHO) Headquarters, Carter Center, Merck & Co., World Bank Headquarters, and Burkina Faso's World Health Organization Africa Onchocerciasis Control Program.

* 1985 – Hoechst-Roussel Award
* 1986 – The Pharmaceutical Society of Japan Award
* 1988 – Uehara Prize
* 1990 – Japan Academy Prize (academics)
* 1992 – Medal with Purple Ribbon
* 1995 – Fujihara Award
* 1997 – Robert Koch Gold Medal
* 1998 – Prince Mahidol Award
* 2000 – Nakanishi Prize (American Chemical Society and Chemical Society of Japan)
* 2005 – Ernest Guenther Award in the Chemistry of Natural Products (American Chemical Society)
* 2007 – Hamao Umezawa Memorial Award
* 2008 – Knight of the Legion of Honour of France
* 2010 – Tetrahedron Prize for Creativity in Organic Chemistry
* 2011 – Arima Award
* 2011 – Order of the Sacred Treasure, Gold and Silver Star
* 2012 – Person of Cultural Merit
* 2014 – Canada Gairdner Global Health Award
* 2015 – Asahi Prize
* 2015 – The Order of Cultural Merit
* 2015 – Nobel Prize in Physiology or Medicine
* 2016 – Japan Bioindustry Association (JBA) Special Honorary Award
* 2016 – Society for Actinomycetes Japan (SAJ) Special Honorary Award
* 2016 – Asian Scientist 100, ''Asian Scientist''

Honorary doctorates

List of honorary doctorates:
* 1992 – Lajos Kossuth University, Hungary
* 1994 – Wesleyan University, USA
* 2016 – Shanghai Jiao Tong University, China
* 2018 – University of St Andrews, Scotland

Learned societies membership

* 1992 – Academy of Sciences Leopoldina
* 1999 – National Academy of Sciences
* 2001 – Japan Academy
* 2002 – Académie des sciences
* 2005 – Russian Academy of Sciences
* 2005 – Royal Society of Chemistry
* 2005 – Academia Europaea
* 2006 – Chinese Academy of Engineering
* 2009 – Japan Society for Bioscience, Biotechnology and Agrochemistry
* 2014 –
* 2016 – Japan Pharmaceutical Association
* 2016 �
Japan Society of Synthetic Organic Chemistry
* 2016 �
Japan Society of Chemotherapy

See also

* Lactacystin, Cerulenin, Andrastin A, Herbimycin, and Neoxaline
* Koji Nakanishi
* Tohru Fukuyama
* Kitasato Shibasaburō
* List of Japanese Nobel laureates
* List of Nobel laureates affiliated with the University of Tokyo

References

External links

Professor Satoshi Omura



Nirasaki Omura Art Museum

Satoshi Ōmura Quotes With Pictures
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{{DEFAULTSORT:Omura, Satoshi
1935 births
Living people
Japanese Nobel laureates
Nobel laureates in Physiology or Medicine
Foreign associates of the National Academy of Sciences
Members of the French Academy of Sciences
Recipients of the Order of the Sacred Treasure, 2nd class
Recipients of the Medal with Purple Ribbon
Knights of the Legion of Honour
21st-century Japanese biochemists
21st-century Japanese inventors
People from Yamanashi Prefecture
Tokyo University of Science alumni
University of Tokyo alumni
Wesleyan University faculty
Japanese art collectors
Museum founders
Recipients of the Order of Culture
Foreign members of the Chinese Academy of Engineering
20th-century Japanese inventors
Scientists from Yamanashi Prefecture