S-777,469 is a drug developed by Shionogi which is a

cannabinoid receptor Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system of vertebrates a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cann ...

agonist, with 128x selectivity for the CB₂ subtype, having a CB₂ affinity of 36nM, and a CB₁ affinity over 4600nM. In

animal studies Animal studies is a recently recognised field in which animals are studied in a variety of cross-disciplinary ways. Scholars who engage in animal studies may be formally trained in a number of diverse fields, including art history, anthropology ...

it showed

antipruritic Antipruritics, abirritants, or anti-itch drugs, are medications that inhibit itching (Latin: ''pruritus''). Itching is often associated with sunburns, allergic reactions, eczema, psoriasis, chickenpox, Fungal infection in animals, fungal infections ...

effects, and passed Phase II human trials for the treatment of

atopic dermatitis Atopic dermatitis (AD), also known as atopic eczema, is a long-term type of inflammation of the skin. Atopic dermatitis is also often called simply eczema but the same term is also used to refer to dermatitis, the larger group of skin conditi ...

, but development was ultimately not continued further.

References

Cannabinoids 2-Pyridones Cyclohexanecarboxylic acids 4-Fluorophenyl compounds {{cannabinoid-stub

See also

References