S-444,823 is a drug developed by
Shionogi which is a
cannabinoid
Cannabinoids () are several structural classes of compounds found primarily in the ''Cannabis'' plant or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoact ...
agonist.
Arimura A. Novel Use of Cannabinoid Receptor Agonist. Patent WO 2005/016351
/ref> It was developed as an antipruritic
Antipruritics, abirritants, or anti-itch drugs, are medications that inhibit itching (Latin: ''pruritus'').
Itching is often associated with sunburns, allergic reactions, eczema, psoriasis, chickenpox, Fungal infection in animals, fungal infections ...
, and has moderate selectivity for the CB2 subtype, having a CB2 affinity of 18nM, and 32x selectivity over the CB1 receptor. In animal studies it showed analgesic effects and strongly reduced itching responses, but without producing side effects such as sedation
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure. Examples of drugs which can be used for sedation include isoflurane, diethyl ether, ...
and catalepsy
Catalepsy (from Ancient Greek , , "seizing, grasping") is a neurological condition characterized by muscular rigidity and fixity of posture regardless of external stimuli, as well as decreased sensitivity to pain.
Signs and symptoms
Sympt ...
that are seen with centrally acting CB1 agonists.
See also
* JTE 7-31
JTE 7-31 is a selective cannabinoid receptor agonist invented by Japan Tobacco. It is a reasonably highly selective CB2 agonist, but still retains appreciable affinity at CB1, with a Ki of 0.088nM at CB2 vs 11nM at CB1.
Legality
JTE 7-31 is il ...
* RQ-00202730
* S-777,469
References
Cannabinoids
Nitrogen heterocycles
Thiazoles
Heterocyclic compounds with 2 rings
{{cannabinoid-stub