RhoGAP domain is an evolutionary conserved

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist o ...

of GTPase activating proteins towards

Rho Rho (uppercase Ρ, lowercase ρ or ; el, ρο or el, ρω, label=none) is the 17th letter of the Greek alphabet. In the system of Greek numerals it has a value of 100. It is derived from Phoenician letter res . Its uppercase form uses the sa ...

Rac RAC or Rac may refer to: Organizations * Radio Amateurs of Canada * RATCH-Australia Corporation, electricity generator * Refugee Action Collective (Victoria), Melbourne, Australia * Religious Action Center of Reform Judaism, US * Rent-A-Center, ...

/ Cdc42-like small

GTPase GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a ...

Human proteins containing this domain

ABR Abr or ABR may refer to: Technology * Available Bit Rate, a service used in ATM networks * Average bitrate, the average amount of data transferred per second * Area border router, in the Open Shortest Path First protocol * Adaptive bit rate, a ...

; ARHGAP1;

ARHGAP10 Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''ARHGAP1'' gene. Interactions ARHGAP1 has been shown to interact with: * BNIP2 * CDC42, and * RHOA Transforming protein RhoA, also known as Ras homolog family ...

; ARHGAP11A; ARHGAP11B;

ARHGAP12 Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''ARHGAP1'' gene. Interactions ARHGAP1 has been shown to interact with: * BNIP2 * CDC42, and * RHOA Transforming protein RhoA, also known as Ras homolog family ...

; ARHGAP15; ARHGAP17;

ARHGAP18 Rho GTPase activating protein 18 is a protein that in humans is encoded by the ''ARHGAP18'' gene. The gene is also known as ''MacGAP'' and ''bA307O14.2''. ARHGAP18 belongs to a family of Rho GTPase-activating proteins that modulate cell signaling ...

; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP23;

ARHGAP24 Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ''ARHGAP24'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gene ...

;

ARHGAP25 Rho GTPase activating protein 25 is a protein that in humans is encoded by the ''ARHGAP25'' gene. The gene is also known as ''KAIA0053''. ARHGAP25 belongs to a family of Rho GTPase-modulating proteins that are implicated in actin remodeling, cell ...

;

ARHGAP26 Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ''ARHGAP26'' gene. Function GRAF1 is a multidomain protein that is necessary f ...

;

ARHGAP27 Rho GTPase activating protein 27 is a protein that in humans is encoded by the ARHGAP27 gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generati ...

; ARHGAP28;

ARHGAP29 ARHGAP29 is a gene located on chromosome 1p22 that encodes Rho GTPase activating protein (GAP) 29, a protein that mediates the cyclical regulation of small GTP binding proteins such as RhoA. Function ARHGAP29 is expressed in the developing face an ...

; ARHGAP30;

ARHGAP4 Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ''ARHGAP4'' gene. It has been shown to regulate cell motility Motility is the ability of an organism to move independently, using metabolic energy. Definitions Mo ...

; ARHGAP5; ARHGAP6;

ARHGAP8 Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ''ARHGAP8'' gene. Function This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate c ...

;

ARHGAP9 Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ''ARHGAP9'' gene. Function This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards sever ...

; BCR; BPGAP1; C1; C5orf5; CDGAP;

CENTD1 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ''ARAP2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelia ...

;

CENTD2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ''ARAP1'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelia ...

;

CENTD3 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ''ARAP3'' gene. This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and p ...

; CHN1; CHN2; DEPDC1; DEPDC1A; DEPDC1B;

DLC1 Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 (STARD12) is a protein which in humans is encoded by the ''DLC1'' gene. This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p22 ...

; FAM13A1; FKSG42; GMIP;

GRLF1 Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the ''GRLF1'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meanin ...

;

HMHA1 Minor histocompatibility protein HA-1 is a protein that in humans is encoded by the ''HMHA1'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gen ...

;

INPP5B Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the ''INPP5B'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." ...

; KIAA1688; LOC553158; MYO9A; MYO9B;

OCRL Inositol polyphosphate 5-phosphatase OCRL-1, also known as Lowe oculocerebrorenal syndrome protein, is an enzyme encoded by the ''OCRL'' gene located on the X chromosome in humans. This gene encodes an inositol polyphosphate 5-phosphatase. The ...

;

OPHN1 Oligophrenin-1 is a protein that in humans is encoded by the ''OPHN1'' gene. Function Oligophrenin 1 has 25 exons and encodes a Rho- GTPase-activating protein. The Rho proteins are important mediators of intracellular signal transduction, whi ...

;

PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the ''PIK3R1'' gene. Function Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Th ...

;

PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the ''PIK3R2'' gene. A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis. Interactions ...

; PRR5; RACGAP1; RACGAP1P; RALBP1; RICH2; RICS;

SH3BP1 SH3 domain-binding protein 1 is a protein that in humans is encoded by the ''SH3BP1'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation' ...

; SLIT1; SNX26; SRGAP1; SRGAP2; SRGAP3;

STARD13 StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the ''STARD13'' gene and a member of the DLC family of proteins. Function and structure STAR ...

;

STARD8 StAR-related lipid transfer domain protein 8 (STARD8) also known as deleted in liver cancer 3 protein (DLC-3) is a protein that in humans is encoded by the ''STARD8'' gene and is a member of the DLC family. Structure and function The protein is ...

; SYDE1; SYDE2;

Notes

References

* * * * Protein domains Peripheral membrane proteins {{membrane-protein-stub