Jean-Baptiste de Sénac (1693–1770) was a French physician, born in the district of

Lombez Lombez ( or ; ) is a commune in the Gers department in southwestern France. Geography Population See also * Lombez Cathedral *Communes of the Gers department The following is a list of the 458 communes of the Gers department of Franc ...

Gascony Gascony (; ) was a province of the southwestern Kingdom of France that succeeded the Duchy of Gascony (602–1453). From the 17th century until the French Revolution (1789–1799), it was part of the combined Province of Guyenne and Gascon ...

France France, officially the French Republic, is a country located primarily in Western Europe. Overseas France, Its overseas regions and territories include French Guiana in South America, Saint Pierre and Miquelon in the Atlantic Ocean#North Atlan ...

Early life and education

Details of Sénac's early life are sketchy. It is generally thought that he studied medicine at the

University of Leiden Leiden University (abbreviated as ''LEI''; ) is a public research university in Leiden, Netherlands. Established in 1575 by William, Prince of Orange as a Protestant institution, it holds the distinction of being the oldest university in the Neth ...

the Netherlands , Terminology of the Low Countries, informally Holland, is a country in Northwestern Europe, with Caribbean Netherlands, overseas territories in the Caribbean. It is the largest of the four constituent countries of the Kingdom of the Nether ...

. He later studied in

London London is the Capital city, capital and List of urban areas in the United Kingdom, largest city of both England and the United Kingdom, with a population of in . London metropolitan area, Its wider metropolitan area is the largest in Wester ...

England England is a Countries of the United Kingdom, country that is part of the United Kingdom. It is located on the island of Great Britain, of which it covers about 62%, and List of islands of England, more than 100 smaller adjacent islands. It ...

, where one of his instructors was John Freind (1675–1728). Beginning in 1723, Sénac practiced medicine in

Paris Paris () is the Capital city, capital and List of communes in France with over 20,000 inhabitants, largest city of France. With an estimated population of 2,048,472 residents in January 2025 in an area of more than , Paris is the List of ci ...

, serving (from 1752 to 1770) as a personal physician to King

Louis XV Louis XV (15 February 1710 – 10 May 1774), known as Louis the Beloved (), was King of France from 1 September 1715 until his death in 1774. He succeeded his great-grandfather Louis XIV at the age of five. Until he reached maturity (then defi ...

Contributions to medicine

Sénac is remembered for important studies of the

heart The heart is a muscular Organ (biology), organ found in humans and other animals. This organ pumps blood through the blood vessels. The heart and blood vessels together make the circulatory system. The pumped blood carries oxygen and nutrie ...

in an era when cardiological medicine was rudimentary. In 1749 he published a book on cardiology called ''Traité de la structure du coeur, de son action, et de ses maladies'' (Treatise on the structure of the heart, its action, and its diseases), an influential work that systematically dealt with

physiological Physiology (; ) is the science, scientific study of function (biology), functions and mechanism (biology), mechanisms in a life, living system. As a branches of science, subdiscipline of biology, physiology focuses on how organisms, organ syst ...

anatomical Anatomy () is the branch of morphology concerned with the study of the internal structure of organisms and their parts. Anatomy is a branch of natural science that deals with the structural organization of living things. It is an old scien ...

and

pathological Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

issues involving the

. In the treatise, he discusses heart disorders and

diseases A disease is a particular abnormal condition that adversely affects the structure or function of all or part of an organism and is not immediately due to any external injury. Diseases are often known to be medical conditions that are asso ...

that he analyzed personally, as well as diagnoses that were determined by other physicians. Many of Sénac's discoveries were derived from

autopsies An autopsy (also referred to as post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death; ...

. He was the first physician to describe the correlation between

atrial fibrillation Atrial fibrillation (AF, AFib or A-fib) is an Heart arrhythmia, abnormal heart rhythm (arrhythmia) characterized by fibrillation, rapid and irregular beating of the Atrium (heart), atrial chambers of the heart. It often begins as short periods ...

and mitral valve disease, as well as the first to provide a comprehensive study of cardiac

hypertrophy Hypertrophy is the increase in the volume of an organ or tissue due to the enlargement of its component cells. It is distinguished from hyperplasia, in which the cells remain approximately the same size but increase in number. Although hypertro ...

. He also conducted research of

cinchona ''Cinchona'' (pronounced or ) is a genus of flowering plants in the family Rubiaceae containing at least 23 species of trees and shrubs. All are native to the Tropical Andes, tropical Andean forests of western South America. A few species are ...

extract and

rhubarb Rhubarb is the fleshy, edible stalks ( petioles) of species and hybrids (culinary rhubarb) of ''Rheum'' in the family Polygonaceae, which are cooked and used for food. The plant is a herbaceous perennial that grows from short, thick rhizomes. ...

as possible treatments for cardiac irregularities. Gabriel Sénac de Meilhan was his son.

References

{{DEFAULTSORT:Senac, Jean-Baptiste de 1693 births 1770 deaths People from Gers French cardiologists 18th-century French physicians Leiden University alumni