Filamins are a class of proteins that hold two
actin filaments at large angles.
Filamin protein in mammals is made up of an actin-binding domain at its
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
that is followed by 24 immunoglobulin-like repeat modules of roughly 95
amino acids. There are two hinge regions; between repeats 15-16 and 23-24. Filamin gets cleaved at these hinge regions to generate smaller fragments of the protein. Filamin has two actin-binding sites with a V-linkage between them, so that it cross-links actin filaments into a network with the filaments orientated almost at right angles to one another.
Filamin proteins include:
*
FLNA
*
FLNB
*
FLNC
Over-expression of FLNA stops the regeneration of
bladder carcinoma (BC) cells, by inhibiting the
cell cycle
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA ( DNA replication) and some of its organelles, and sub ...
and inducing
apoptosis of BC cells.
FLNA has also been shown to reduce the
mobility and invasion abilities of BC cells.
References
External links
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Human proteins
Proteins
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