The Fibronectin type III domain is an evolutionarily conserved

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist o ...

that is widely found in animal proteins. The

fibronectin Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen ...

protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100

amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha ...

s long and possesses a

beta sandwich Beta-sandwich, β-sandwich domains consisting of 80 to 350 amino acids occur commonly in proteins. They are characterized by two opposing antiparallel beta sheets (β-sheets). The number of strands found in such domains may differ from one protein ...

structure. Of the three fibronectin-type domains, type III is the only one without

disulfide bonding In biochemistry, a disulfide (or disulphide in British English) refers to a functional group with the structure . The linkage is also called an SS-bond or sometimes a disulfide bridge and is usually derived by the coupling of two thiol groups. In ...

present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins.

Human proteins containing this domain

ABI3BP ABI family member 3 binding protein is a protein that in humans is encoded by the ABI3BP gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generat ...

; ANKFN1;

ASTN2 Automatic Switched Transport Network (ASTN) allows traffic paths to be set up through a switched network automatically. The term ASTN replaces the term ASON (Automatically Switched Optical Network) and is often used interchangeably with GMPLS (Ge ...

; AXL; BOC; BZRAP1;

C20orf75 C, or c, is the third letter in the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''cee'' (pronounced ), plural ''cees''. History "C ...

; CDON;

CHL1 Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the ''CHL1'' gene. CHL1 is a cell adhesion molecule Cell adhesion molecules (CAMs) are a subset of cell surface pr ...

; CMYA5;

CNTFR The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the survival of neurons. This receptor is most closely related to the interleukin-6 receptor. ...

; CNTN1;

CNTN2 Contactin-2 is a protein that in humans is encoded by the ''CNTN2'' gene. Function The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein th ...

;

CNTN3 Contactin-3 is a protein that in humans is encoded by the ''CNTN3'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ...

;

CNTN4 Contactin-4 is a protein that in humans is encoded by the ''CNTN4'' gene. The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions ...

; CNTN5; CNTN6; COL12A1;

COL14A1 Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the ''COL14A1'' gene. It likely plays a role in collagen binding and cell-cell adhesion Cell adhesion is the process by which cells interact and attach to neighbouring cell ...

; COL20A1; COL7A1;

CRLF1 Cytokine receptor-like factor 1 is a protein that in humans is encoded by the ''CRLF1'' gene. Function This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine f ...

;

CRLF3 Cytokine receptor-like factor 3 is a protein that in humans is encoded by the ''CRLF3'' gene. Model organisms Model organisms have been used in the study of CRLF3 function. A conditional knockout mouse line, called ''Crlf3tm1a(KOMP)Wtsi'' wa ...

; CSF2RB;

CSF3R The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the ''CSF3R'' gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulati ...

; DCC; DSCAM;

DSCAML1 Down syndrome cell adhesion molecule like 1 is a protein in humans that is encoded by the DSCAML1 gene. See also * DSCAM, Down syndrome cell adhesion molecule * Fibronectin type III domain * Immunoglobulin superfamily References Exter ...

;

EBI3 Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the ''EBI3'' gene. Function This gene was identified by the induction of its expression in B lymphocytes by Epst ...

;

EGFLAM Pikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is encoded by the ''EGFLAM'' gene. Pikachurin is a dystroglycan-interacting protein ...

; EPHA1;

EPHA10 EPH receptor A10 is a protein in humans that is encoded by the EPHA10 gene. Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating ce ...

; EPHA2;

EPHA3 EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the ''EPHA3'' gene. Function This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been ...

;

EPHA4 EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the ''EPHA4'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated i ...

; EPHA5; EPHA6; EPHA7; EPHA8;

EPHB1 Ephrin type-B receptor 1 is a protein that in humans is encoded by the ''EPHB1'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their str ...

;

EPHB2 Ephrin type-B receptor 2 is a protein that in humans is encoded by the ''EPHB2'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their stru ...

; EPHB3; EPHB4; EPHB6; EPOR; FANK1;

FLRT1 Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene. Function This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function ...

;

FLRT2 Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the ''FLRT2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of here ...

; FLRT3;

FN1 Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, f ...

; FNDC1;

FNDC3A Fibronectin type-III domain-containing protein 3a is a protein that in humans is encoded by the ''FNDC3A'' gene. References Further reading

* * * * * * * * * {{gene-13-stub ...

; FNDC3B; FNDC4; FNDC5; FNDC7; FNDC8; FSD1; FSD1L;

FSD2 FSD may refer to: Places * Faisalabad, Pakistan * Sioux Falls Regional Airport, in South Dakota, US (IATA code FSD) Education * Ferndale School District, Washington * Florida School for the Deaf, St. Augustine, Florida * Framwellgate School Durham ...

; GHR; HCFC1;

HCFC2 Chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) are fully or partly halogenated hydrocarbons that contain carbon (C), hydrogen (H), chlorine (Cl), and fluorine (F), produced as volatile derivatives of methane, ethane, and propan ...

; HUGO; IFNGR2;

IGF1R The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2 ...

; IGSF22; IGSF9; IGSF9B;

IL4R The interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene. Function This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to ...

;

IL11RA Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor The interleukin 11 receptor is a type I cytokine receptor, binding interleukin 11. It is a heterodimer composed of an interleukin 11 receptor alpha subunit Int ...

; IL12B;

IL12RB1 IL-1 may refer to: * Interleukin 1, a protein * Illinois's 1st congressional district * Illinois Route 1 * Building 1 of Infinite Loop (street) The Apple Campus is the former corporate headquarters of Apple Inc. from 1993 until 2017, when it wa ...

;

IL12RB2 Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. ''IL12RB2'' orthologs have been identified in all mammals for which complete genome data are available. The protein encoded by this ...

;

IL20RB Interleukin 20 Receptor (biochemistry), receptor, beta subunit (IL20R2 or IL20RB) is a Protein subunit, subunit of the Interleukin-20 receptor, interleukin-20 receptor and interleukin-22 receptor. It is believed to be involved in both pro-inflamma ...

; IL23R;

IL27RA Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotei ...

; IL31RA;

IL6R Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Function Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an importa ...

;

IL6ST Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor f ...

;

IL7R The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain recep ...

;

INSR The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose hom ...

; INSRR; ITGB4; KAL1; KALRN;

L1CAM L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. This protein, of 200-220 kDa, is a neuronal cell adhesion molecule with a strong implication in cell migration, adhesion, neurite ou ...

;

LEPR Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor, a protein that in humans is encoded by the ''LEPR'' gene. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 ...

; LIFR; LRFN2; LRFN3;

LRFN4 Leucine rich repeat and fibronectin type III domain containing 4 is a protein that in humans is encoded by the ''LRFN4'' gene. See also *Fibronectin type III domain *Leucine rich repeat References Further reading

* {{gene-11 ...

; LRFN5; LRIT1;

LRRN1 Leucine-rich repeat neuronal protein 1 is a protein that in humans is encoded by the ''LRRN1'' gene. References Further reading

* * * * * * * * * {{gene-3-stub ...

;

LRRN3 Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 (NLRR-3), is a protein that in humans is encoded by the ''LRRN3'' gene. Gene The LRRN3 is located on human chromosome 7, at 7q31.1. It contains 6 distin ...

; MERTK;

MID1 MID1 is a protein that belongs to the Tripartite motif family (TRIM) and is also known as TRIM18. The ''MID1'' gene is located on the short arm of the X chromosome and loss-of-function mutations in this gene are causative of the X-linked form of a ...

;

MID2 Midline-2 is a protein that in humans is encoded by the ''MID2'' gene. Function The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and ...

; MPL; MYBPC1;

MYBPC2 Myosin binding protein C, fast type is a protein that in humans is encoded by the MYBPC2 gene. Function This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each ...

; MYBPC3; MYBPH; MYBPHL; MYLK; MYOM1; MYOM2; MYOM3;

NCAM1 Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discover ...

; NCAM2; NEO1;

NFASC Neurofascin is a protein that in humans is encoded by the ''NFASC'' gene. Function Neurofascin is an L1 family immunoglobulin cell adhesion molecule (see L1CAM) involved in axon subcellular targeting and synapse formation during neural develop ...

; NOPE;

NPHS1 Nephrin is a protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells. Nephrin is ...

; NRCAM;

OBSCN Obscurin is a protein that in humans is encoded by the ''OBSCN'' gene. Obscurin belongs to the family of giant sarcomeric signaling proteins that includes titin and nebulin. Obscurin is expressed in cardiac and skeletal muscle, and plays a role in ...

; OBSL1;

OSMR Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins for oncostatin M, that in humans is encoded by the ''OSMR'' gene. OSMR is a member of the type I cytokine receptor famil ...

;

PHYHIP Phytanoyl-CoA 2-hydroxylase interacting protein is a protein that in humans is encoded by the PHYHIP gene. References Further reading

* {{gene-8-stub ...

;

PHYHIPL Phytanoyl-CoA hydroxylase-interacting protein-like is an enzyme that in humans is encoded by the ''PHYHIPL'' gene. References Further reading

* * * * * * * * * {{gene-10-stub ...

; PRLR; PRODH2; PTPRB; PTPRC; PTPRD; PTPRF;

PTPRG Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the ''PTPRG'' gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules ...

;

PTPRH Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the ''PTPRH'' gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules th ...

; PTPRJ; PTPRK; PTPRM; PTPRO; PTPRS; PTPRT; PTPRU;

PTPRZ1 Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the ''PTPRZ1'' gene. Function This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I ...

; PTPsigma; PUNC;

RIMBP2 RIMS binding protein 2 is a protein that in humans is encoded by the RIMBP2 gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''bi ...

; ROBO1;

ROBO2 Roundabout homolog 2 is a protein that in humans is encoded by the ''ROBO2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''bir ...

;

ROBO3 Roundabout homolog 3 is a protein that in humans is encoded by the ''ROBO3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''bir ...

;

ROBO4 Roundabout homolog 4 is a protein that in humans is encoded by the ''ROBO4'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''bir ...

; ROS1;

SDK1 Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene. Function The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thir ...

;

SDK2 Protein sidekick-2 is a protein that in humans is encoded by the ''SDK2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth ...

; SNED1; SORL1; SPEG; TEK; TIE1; TNC; TNN; TNR;

TNXB A member of the tenascin family, tenascin X (TN-X) also known as flexillin or hexabrachion-like protein is a 450kDa glycoprotein that is expressed in connective tissues. TN-X possesses a modular structure composed, from the N- to the C-terminal p ...

; TRIM36; TRIM42; TRIM46; TRIM67; TRIM9; TTN; TYRO3; UMODL1; USH2A; VASN; VWA1; dJ34F7.1; fmi;

References

* * * {{refend Protein domains Single-pass transmembrane proteins