Diego Domínguez may refer to:
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Diego Domínguez (rugby union) (born 1966), Argentine rugby union player for Argentina and Italy
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Diego Domínguez (rally driver) (born 1972), rally driver from Paraguay
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Diego Domínguez Jr. (born 2000), his son, Paraguayan rally driver
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Diego Domínguez (actor) (born 1991), Spanish actor and singer
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Diego Domínguez (canoeist) (born 2003), Spanish sprint canoeist
{{hndis, Dominguez, Diego