Cyclin-dependent kinase 2-associated protein 1 is an
enzyme that in humans is encoded by the ''CDK2AP1''
gene.
Function
The protein encoded by this gene is a specific
CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for
proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called protease ...
. This protein was found to also interact with DNA polymerase alpha/
primase and mediate the
phosphorylation
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, wh ...
of the large p180 subunit, which suggested the regulatory role in DNA replication during
S phase
S phase (Synthesis Phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication of the genome is critical to successful cell division, the processes that occur during ...
of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal
keratinocytes.
Interactions
CDK2AP1 has been shown to
interact with
Cyclin-dependent kinase 2
Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the ''CDK2'' gene. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein ...
.
It interacts with unnamed protein product (BC006130) which may mediate inhibitory effect of CDK2AP1 on cell proliferation.
References
External links
*
Further reading
*
*
*
*
*
*
*
*
*
*
{{gene-12-stub