Adolf Stachel (born 28 February 1913 in
Augsburg
Augsburg (; bar , Augschburg , links=https://en.wikipedia.org/wiki/Swabian_German , label=Swabian German, , ) is a city in Swabia, Bavaria, Germany, around west of Bavarian capital Munich. It is a university town and regional seat of the ' ...
, died 1971 in
Frankfurt am Main
Frankfurt, officially Frankfurt am Main (; Hessian: , "Frank ford on the Main"), is the most populous city in the German state of Hesse. Its 791,000 inhabitants as of 2022 make it the fifth-most populous city in Germany. Located on its na ...
) was a German chemist, researcher and inventor, who worked as a researcher at the chemical and pharmaceutical company
Cassella
Cassella AG, formerly Leopold Cassella & Co. and Cassella Farbwerke Mainkur AG, commonly known as Cassella, was a German chemical and pharmaceutical company with headquarters in Frankfurt am Main. Founded in 1798 in the Frankfurt Jewish Alley by ...
(now
Sanofi
Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. Originally, the corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 2004, Sanofi-Syn ...
) in
Frankfurt-Fechenheim
Fechenheim is a quarter of Frankfurt am Main, Germany. It is part of the ''Ortsbezirk
A ''Stadtbezirk'' (also called ''Ortsbezirk'' in Hesse and Rhineland-Palatinate) is an administrative division in Germany, which is part of a larger city. I ...
for much of his career.
He held a doctoral degree in chemistry (
Doktoringenieur
The Doktoringenieur (acronym Dr.-Ing., also ''Doktor der Ingenieurwissenschaften'') is the Germany, German engineering doctorate degree, comparable to the Doctor of Engineering, Engineering Doctorate, Doctor of Science, Doctor of Science (Engineer ...
) from the
Technische Hochschule München. Early in his career, he was a mentee and collaborator of the Nobel Prize-winning chemist
Hans Fischer
Hans Fischer (; 27 July 1881 – 31 March 1945) was a German organic chemist and the recipient of the 1930 Nobel Prize for Chemistry "for his researches into the constitution of haemin and chlorophyll and especially for his synthesis of haem ...
, who was his doctoral supervisor. He later became a researcher at Cassella. His patents were related to basically substituted heterocyclic compounds, e.g. 2,3-benzotriazine-4(3H)-one derivatives (coumarin), and basically substituted 1H,3H)-quinazoline-2-thion-4-one derivatives, having excellent coronary dilator properties. Patentee was Cassella. When working at Cassella, he was a close collaborator of Armin K.W. Kutzsche. Together with
Werner Zerweck
Werner Zerweck (14 March 1899 in Munich – 10 September 1965) was a German chemist, inventor and industrial leader, who served as CEO of the chemical and pharmaceutical company Cassella (later merged to become part of Sanofi) from 1953 to 1963. ...
they developed Nu-nu-dibenzylsulfamyl benzoic acid, US patent 2805250 A, in the early 1950s.
Other frequent collaborators were Rudi Beyerle, Rolf-Eberhard Nitz and Klaus Resag.
He was married to Ingeburg Lydia Katharina Rodenhausen (1923-2008).
Selected publications
*Stachel A (1939), ''Über Dimethoxy-dipyrromethene und Dihalogendipyrromethene und ihre Umsetzungen'', doctoral dissertation,
Technische Hochschule München, 23 February 1939, 31 pages.
*
Fischer H, Stachel A (1939), "Über Dimethoxy-dipyrromethene und Dihalogen-dipyrromethene und ihre Umsetzungen," ''
Hoppe-Seyler's Zeitschrift für physiologische Chemie'' (= ''Biological Chemistry''), Volume 258, Issue 2–3, pp. 121–136,
doi10.1515/bchm2.1939.258.2-3.121 Based on the above dissertation.
*Stachel A, Kutzsche A,
Zerweck W (1957)
Nu-nu-dibenzylsulfamyl benzoic acid US Patent US 2805250 A.
*Beyerle R, Nitz RE, Resag K, Stachel A (1971)
Pharmacologically-active trimethoxybenzoxyalkyl-piperazino(1')compounds US Patent US 3594384 A.
*Stachel A, Nitz RE (1966)
Method of increasing sodium chloride excretion US Patent US 3250676 A.
*Stachel A, Nitz RE, Resag K, Kreiskott H (1968)
Theophylline derivatives US Patent US 3399195 A.
*Beyerle R, Stachel A, Nitz RE, Resag K (1970)
Process for the production of coumarin derivatives US Patent US 3541097 A.
*Beyerle R, Nitz RE, Resag K, Schraven E, Stachel A (1972)
3-({60 -substituted amino-{62 -alkoxybenzoxy-propyl)-6,7-or-6,7,8-alkoxy-1,2,3-benzotriazine-4(3h)-ones US Patent US 3706739 A.
*Stachel A, Schraven E, Nitz RE, Resag K, Beyerle R (1973)
3-(alpha-substituted amino-beta-alkoxybenzoxypropyl)-6,7-or 6,7,8-alkoxy-1,2,3-benzotriazine-4(3h)-ones US Patent US 3751413 A.
*Beyerle R, Stachel A (1973)
Basically substituted 2,4-(1h,3h)-quinazolindione derivatives US Patent US 3718648 A.
*Stachel A, Beyerle R, Kunze W, Nitz RE, Scholtholt J (1975)
Basically substituted 1(2H)-phthalazinone derivatives US Patent US 3894015 A.
*Beyerle R, Stachel A (1976)
Piperazino substituted coumarin derivatives US Patent US 3959281 A.
References
{{DEFAULTSORT:Stachel, Adolf
20th-century German chemists
Cassella people
Scientists from Augsburg
1913 births
1971 deaths
Technical University of Munich alumni