3,4-Methylenedioxyphentermine (MDPH) is a lesser-known drug of the
amphetamine
Amphetamine (contracted from Alpha and beta carbon, alpha-methylphenethylamine, methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, an ...
family. MDPH was first synthesized by
Alexander Shulgin
Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American biochemist, broad researcher of synthetic psychoactive compounds, and author of works regarding these, who independently explored the organic chemistry and ph ...
. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPH.
In his book ''
PiHKAL (Phenethylamines i Have Known And Loved)'', the dosage range is listed as 160–240 mg, and the duration as 3–5 hours. MDPH's effects are very similar to those of
MDA
MDA, mda or variants may refer to:
Businesses and organizations Political parties
* Meghalaya Democratic Alliance (2003–2008), in India
* Meghalaya Democratic Alliance (2018–present), in India
* Movement for Democracy in Africa, in Burkina F ...
: they both are smooth and "stoning," and do not cause any visuals. They also alter dreams and dream patterns. Shulgin describes MDPH as a promoter; it promotes the effects of other drugs, similarly to
2C-D
2C-D, also known as 2C-M or as 2,5-dimethoxy-4-methylphenethylamine, is a psychedelic drug of the 2C family that is sometimes used as an entheogen. It was first synthesized in 1970 by a team from the Texas Research Institute of Mental Sciences, a ...
.
The ''N''-methyl
derivative
In mathematics, the derivative is a fundamental tool that quantifies the sensitivity to change of a function's output with respect to its input. The derivative of a function of a single variable at a chosen input value, when it exists, is t ...
,
3,4-methylenedioxy-''N''-methylphentermine (MDMPH), has been described by Shulgin as lacking
MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (tablet form), and molly (crystal form), is an empathogen–entactogenic drug with stimulant and minor Psychedelic drug, psychedelic properties. In studies, it has been used ...
-like effects.
Accordingly, MDMPH, as well as MDPH, were found to be inactive as
serotonin releasing agent
A serotonin releasing agent (SRA) is a type of drug that induces the release of serotonin into the neuronal synaptic cleft. A selective serotonin releasing agent (SSRA) is an SRA with less significant or no efficacy in producing neurotransmitter ...
s ''
in vitro
''In vitro'' (meaning ''in glass'', or ''in the glass'') Research, studies are performed with Cell (biology), cells or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in ...
''.
Legality
United Kingdom
This substance is a Class A drug in the
Drugs controlled by the UK Misuse of Drugs Act
The Misuse of Drugs Act 1971 (c. 38) is an act of the Parliament of the United Kingdom. It represents action in line with treaty commitments under the Single Convention on Narcotic Drugs, the Convention on Psychotropic Substances, and the Un ...
.
See also
*
3,4-Dichloroamphetamine
3,4-Dichloroamphetamine (3,4-DCA), is an amphetamine derived drug invented by Eli Lilly in the 1960s, which has a number of pharmacological actions. It acts as a highly potent and selective serotonin releasing agent (SSRA) and binds to the sero ...
*
Cericlamine
Cericlamine (INN; developmental code JO-1017) is a potent and moderately selective serotonin reuptake inhibitor (SSRI) of the amphetamine family (specifically, a derivative of phentermine, and closely related to chlorphentermine, a highly selecti ...
*
Chlorphentermine
Chlorphentermine, sold under the brand names Apsedon, Desopimon, and Lucofen, is a serotonergic appetite suppressant of the amphetamine family. Developed in 1962, it is the ''para''- chloro derivative of the better-known appetite suppressant ph ...
*
Cloforex
Cloforex (Oberex) is an anorectic of the amphetamine class. It is a prodrug to chlorphentermine. It never became a mass produced drug in part due to the side effects found in mice. Mice who consumed 75 mg of cloforex a day experienced weight los ...
*
Clortermine
Clortermine (Voranil) was developed by Ciba in the 1960s and is an anorectic drug of the amphetamine class. It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermi ...
*
Etolorex
Etolorex is a central nervous system (CNS) stimulant and anorectic drug belonging to the substituted amphetamine and phenethylamine chemical classes. Etolorex was derived from phentermine, an amphetamine derivative in its own right frequently pre ...
*
Methylenedioxyphenmetrazine
3,4-Methylenedioxyphenmetrazine (MDPM or 3-MDPM) is a recreational designer drug with stimulant effects. It is a substituted phenylmorpholine derivative, closely related to better known drugs such as phenmetrazine and 3-fluorophenmetrazine. It h ...
*
Phentermine
Phentermine, sold under the brand name Adipex-P among others, is a medication used together with diet and exercise to treat obesity. It is available by itself or as the combination phentermine/topiramate. Phentermine is taken by mouth.
Com ...
References
{{Phenethylamines
Methylenedioxyphenethylamines
Monoamine releasing agents
Phentermines