ψ-DOM, or psi-DOM, also known as 2,6-dimethoxy-4-methylamphetamine, is a

hallucinogenic Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, moo ...

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...

drug A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via insufflation (medicine), inhalation, drug i ...

of the Ψ-PEA family and a structural

isomer In chemistry, isomers are molecules or polyatomic ions with identical molecular formula – that is, the same number of atoms of each element (chemistry), element – but distinct arrangements of atoms in space. ''Isomerism'' refers to the exi ...

of the better-known hallucinogen DOM. ψ-DOM was first reported by

Alexander Shulgin Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American biochemist, broad researcher of synthetic psychoactive compounds, and author of works regarding these, who independently explored the organic chemistry and ph ...

in his book ''

PiHKAL ''PiHKAL: A Chemical Love Story'' is a book by Alexander Shulgin and Ann Shulgin published in 1991. The subject of the work is Psychoactive drug, psychoactive phenethylamine Derivative (chemistry), chemical derivatives, notably those that act ...

''.ψ-DOM Entry in PiHKAL
/ref> ψ-DOM has similar effects to DOM, but is only around one third to one half the potency, with an active dose reported to be between 15 and 25 milligrams. The effects of ψ-DOM last for around six to eight hours. The activity of ψ-DOM (and

ψ-2C-T-4 2C-T-4, also known as 4-isopropylthio-2,5-dimethoxyphenethylamine, is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and is used as entheogenic recreational drug. Effects 2C-T-4 produces psychedelic ...

) demonstrates that the two methoxy groups on the psychedelic phenethylamines are not strictly limited to the 2,5-positions on the phenyl ring. Indeed, any of the 2Cx or DOx series of drugs could alternatively be made as the 2,6-isomer and would still be expected to show similar activity, although slightly less potent. In theory this would vastly expand the range of different hallucinogens that could be derived from this family of drugs. The 2,6-isomer of another similar drug 2C-D-FLY (see

2C-B-FLY 2C-B-FLY is a psychedelic and designer drug of the phenethylamine, 2C, and FLY families. It was first synthesized in 1996 by Aaron Monte, Professor of Chemistry at UW-La Crosse. This molecule was researched by Alexander Shulgin, and it was Ann ...

) has also been made by

David E. Nichols David Earl Nichols (born December 23, 1944, Covington, Kentucky) is an American pharmacologist and medicinal chemist. Previously the Robert C. and Charlotte P. Anderson Distinguished Chair in Pharmacology at Purdue University, Nichols has worke ...

and found to be active, this might by extension be referred to as ψ-2C-D-FLY.

References

{{Phenethylamines Ψ-PEA (psychedelics) Psychedelic phenethylamines Substituted amphetamines

See also

References