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Wogonin
Wogonin is an O-methylated flavone, a flavonoid-like chemical compound which is found in ''Scutellaria baicalensis''. The glycosides of wogonin are known as wogonosides. For example, oroxindin is a wogonin glucuronide isolated from '' Oroxylum indicum''. It is one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement. Wogonin has been found in one study to have anxiolytic properties in mice at doses of 7.5 to 30 mg/kg, without exhibiting the sedative and muscle-relaxing properties of benzodiazepines. Preliminary ''in vitro'' studies have shown pharmacological effects that indicate wogonin may have anti-tumor properties. Wogonin has also been found to possess anticonvulsant effects. It acts as a positive allosteric modulator of the benzodiazepine site The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norwogonin
Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in ''Scutellaria baicalensis'' (Baikal skullcap). It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin Tropoflavin, also known as 7,8-dihydroxyflavone, is a naturally occurring flavone found in '' Godmania aesculifolia'', '' Tridax procumbens'', and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of ... (7,8-DHF). See also * Tropomyosin receptor kinase B § Agonists References Flavones TrkB agonists {{aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |