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Post-exertional Symptom Exacerbation
Post-exertional malaise (PEM), sometimes referred to as post-exertional symptom exacerbation (PESE) or post-exertional neuroimmune exhaustion (PENE), is a worsening of symptoms that occurs after minimal exertion. It is the hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and common in long COVID and fibromyalgia. PEM is often severe enough to be disabling, and is triggered by ordinary activities that healthy people tolerate. Typically, it begins 12–48 hours after the activity that triggers it, and lasts for days, but this is highly variable and may persist much longer. Management of PEM is symptom-based, and patients are recommended to Pacing (activity management), pace their activities to avoid triggering PEM. History and terminology One of the first definitions of ME/CFS, the Holmes Criteria published in 1988, does not use the term ''post-exertional malaise'' but describes prolonged fatigue after exercise as a symptom. The term was later used ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling Chronic condition, chronic illness. People with ME/CFS experience profound fatigue that does not go away with rest, as well as sleep issues and problems with memory or concentration. The Pathognomonic, hallmark symptom is post-exertional malaise (PEM), a worsening of the illness which can start immediately or hours to days after even minor physical or mental activity. This "crash" can last from hours or days to several months. Further common symptoms include orthostatic intolerance, dizziness or faintness when upright and pain. The cause of the disease is unknown. ME/CFS often starts after an infection, such as infectious mononucleosis, mononucleosis. It can run in families, but no genes that contribute to ME/CFS have been confirmed. ME/CFS is associated with changes in the nervous and immune systems, as well as in energy production. Diagnosis is based on distinctive symptoms, and a differential diag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
