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Forward Pharmacology
In the field of drug discovery, classical pharmacology, also known as forward pharmacology, or phenotypic drug discovery (PDD), relies on phenotypic screening (screening in intact cells or whole organisms) of chemical library, chemical libraries of synthetic small molecules, natural products or extracts to identify substances that have a desirable therapeutic effect. Using the techniques of medicinal chemistry, the potency, selectivity, and other properties of these screening hits are optimized to produce candidate drugs. Historical background Classical pharmacology traditionally has been the basis for the discovery of new drugs. Compounds are screened in cellular or animal models of disease to identify compounds that cause a desirable change in phenotype. Only after the compounds have been discovered, an effort is made to determine the biological target of the compounds through target validation experiments often involving chemoproteomics. More recently it has become popular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forward And Reverse Pharmacology
Forward is a relative direction, the opposite of backward. Forward may also refer to: People * Forward (surname) Sports * Forward (association football) * Forward (basketball), including: ** Point forward ** Power forward (basketball) ** Small forward * Forward (ice hockey) ** Power forward (ice hockey) * In rugby football: ** Forwards (rugby league), in rugby league football ** Forwards (rugby union), in rugby union football * Forward Sports, a Pakistan sportswear brand * BK Forward, a Swedish club for association football and bandy Politics * Avante (political party) (Portuguese for ''forward''), a political party in Brazil * Forward (Belgium), a political party in Belgium * Forward (Denmark), a political party in Denmark * Forward (Greenland), a political party in Greenland * Forward Party (United States), a centrist American political party * Kadima (Hebrew for ''forward''), a political party in Israel * La République En Marche! (sometimes translated as ''Forward! ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
