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Zrinka Tamburašev
Zrinka Tamburašev was a Croatian scientist known for her work in the development of antibiotics such as oxytetracycline and azithromycin. Early life Tamburašev was born in Sisak, Kingdom of Yugoslavia, in 1921. She graduated in 1948 from the Chemical-Technological Department of the Technical Faculty in Zagreb and earned her doctorate in 1965. Career She joined the research institute of the pharmaceutical company Pliva, PLIVA in 1957, where she made several discoveries and patents in departments of microbiology, biochemistry, and biotechnology. While at PLIVA she led the group for semisynthetic macrolides from 1972 to 1974, and in 1974 she was named the head of the natural products department. In the mid-1960s, she worked with Slobodan Đokić on erythromycin A derivatives and on sulfonamide derivatives of erythromycylamine, with the idea of combining the properties of erythromycin and sulfonamides. She began work on the synthesis of individual phases for the preparation of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxytetracycline
Oxytetracycline is a broad-spectrum tetracycline antibiotic, the second of the group to be discovered. Oxytetracycline works by interfering with the ability of bacteria to produce essential proteins. Without these proteins, the bacteria cannot grow, multiply and increase in numbers. Oxytetracycline therefore stops the spread of the infection, and the remaining bacteria are killed by the immune system or eventually die. Oxytetracycline is active against a wide variety of bacteria. However, some strains of bacteria have developed resistance to this antibiotic, which has reduced its effectiveness for treating some types of infections. Oxytetracycline is used to treat infections caused by ''Chlamydia'', such as psittacosis, trachoma, and urethritis, and infections caused by '' Mycoplasma'' organisms, such as pneumonia. Oxytetracycline is used to treat acne, due to its activity against the bacteria on the skin that influence the development of acne ('' Cutibacterium acnes''). It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
