|
Uncinate Fasciculus
The uncinate fasciculus is a white matter association tract in the human brain that connects parts of the limbic system such as the temporal pole, anterior parahippocampus, and amygdala in the temporal lobe with inferior portions of the frontal lobe such as the orbitofrontal cortex. Its function is unknown though it is affected in several psychiatric conditions. It is one of the last white matter tracts to mature in the human brain. Anatomy The uncinate fasciculus is a hook-shaped bundle of axons that links anterior portions of the temporal lobe with the inferior frontal gyrus and the lower surfaces of the frontal lobe. It arises in the anterior temporal lobe and amygdala, in the temporal lobe curving in an upward pathway behind the external capsule inward of the insular cortex and continuing up into the posterior part of the orbital gyrus. It does not appear to have cell bodies in the hippocampus proper. The average length of the uncinate fasciculus is 45 mm with a ran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tractography
In neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, ..., tractography is a 3D modeling technique used to visually represent nerve tracts using data collected by diffusion MRI. It uses special techniques of magnetic resonance imaging (MRI) and computer-based diffusion MRI. The results are presented in two- and three-dimensional images called tractograms. In addition to the long tracts that connect the brain to the rest of the body, there are complicated neural circuits formed by short connections among different Cerebral cortex, cortical and subcortical regions. The existence of these tracts and circuits has been revealed by histochemistry and biology, biological techniques on post-mortem specimens. Nerve tracts are not identifiable by direct exam, computed tomography, CT ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diffusion Tensor Imaging
Diffusion-weighted magnetic resonance imaging (DWI or DW-MRI) is the use of specific MRI sequences as well as software that generates images from the resulting data that uses the diffusion of water molecules to generate contrast in MR images. It allows the mapping of the diffusion process of molecules, mainly water, in biological tissues, in vivo and non-invasively. Molecular diffusion in tissues is not random, but reflects interactions with many obstacles, such as macromolecules, fibers, and membranes. Water molecule diffusion patterns can therefore reveal microscopic details about tissue architecture, either normal or in a diseased state. A special kind of DWI, diffusion tensor imaging (DTI), has been used extensively to map white matter tractography in the brain. Introduction In diffusion weighted imaging (DWI), the intensity of each image element (voxel) reflects the best estimate of the rate of water diffusion at that location. Because the mobility of water is driven by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the average life expectancy following diagnosis is three to twelve years. The causes of Alzheimer's disease remain poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of apolipoprotein E. Other risk factors include a history of head injury, clinical depression, and high blood pressure. The progression of the di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phineas Gage
Phineas P. Gage (18231860) was an American railroad construction foreman remembered for his improbable survival of an accident in which a large iron rod was driven completely through his head, destroying much of his brain's left frontal lobe, and for that injury's reported effects on his personality and behavior over the remaining 12 years of his lifeeffects sufficiently profound that friends saw him (for a time at least) as "no longer Gage". Long known as the "American Crowbar Case"once termed "the case which more than all others is to excite our wonder, impair the value of prognosis, and even to subvert our doctrines"Phineas Gage influenced 19th-century discussion about the mind and brain, debate on cerebral , and was perhaps the first case to suggest the brain's role in , and that damage to specific parts of the brain might induce specific mental changes. Gage is a fixture in the curricula of neurology, psychology, and neuroscience, one of "the great medical curiosit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brodmann Area 38
Brodmann area 38, also BA38 or temporopolar area 38 (H), is part of the temporal cortex in the human brain. BA 38 is at the anterior end of the temporal lobe, known as the temporal pole. BA38 is a subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. It is located primarily in the most rostral portions of the superior temporal gyrus and the middle temporal gyrus. Cytoarchitecturally it is bounded caudally by the inferior temporal area 20, the middle temporal area 21, the superior temporal area 22 and the ectorhinal area 36. The temporal pole is a paralimbic region involved in high level semantic representation and socio-emotional processing. The uncinate fasciculus provides a direct bidirectional path to the orbitofrontal cortex, allowing mnemonic representations stored in the temporal pole to bias decision making in the frontal lobe. The temporal pole appears to be a convergence zone where concepts (also known as semantic memories) that are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schizophrenia
Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, flat or inappropriate affect. Symptoms Prodrome, develop gradually and typically begin during young adulthood and rarely resolve. There is no objective diagnostic test; diagnosis is based on observed behavior, a psychiatric history that includes the person's reported experiences, and reports of others familiar with the person. For a diagnosis of schizophrenia, the described symptoms need to have been present for at least six months (according to the DSM-5) or one month (according to the ICD-11). Many people with schizophrenia have other mental disorders, especially mood disorder, mood, anxiety disorder, anxiety, and substance use disorders, substance use disorders, as well as obsessive–compulsive disorder (OCD). About 0.3% to 0.7% of peo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Social Anxiety
Social anxiety is the anxiety and fear specifically linked to being in social settings (i.e., interacting with others). Some categories of disorders associated with social anxiety include anxiety disorders, mood disorders, autism spectrum disorders, eating disorders, and substance use disorders. Individuals with higher levels of social anxiety often avert their gazes, show fewer facial expressions, and show difficulty with initiating and maintaining a conversation. Social anxiety commonly manifests itself in the teenage years and can be persistent throughout life; however, people who experience problems in their daily functioning for an extended period of time can develop social anxiety disorder. Trait social anxiety, the stable tendency to experience this anxiety, can be distinguished from state anxiety, the momentary response to a particular social stimulus. Half of the individuals with any social fears meet the criteria for social anxiety disorder. Age, culture, and gender ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peabody Picture Vocabulary Test
The Peabody Picture Vocabulary Test, the 2007 edition of which is known as the PPVT-IV, is an untimed test of receptive vocabulary for Standard American English and is intended to provide a quick estimate of the examinee's receptive vocabulary ability. It can be used with the Expressive Vocabulary Test-Second Edition (EVT-2) to make a direct comparison between the examinee's receptive and expressive vocabulary skills. The PPVT was developed in 1959 by special education specialists Lloyd M. Dunn and Leota M. Dunn. The current version lists L.M. Dunn and his son D.M. Dunn as authors. Procedure The test is given verbally and takes between twenty and thirty minutes to complete. No reading is required by the individual, and scoring is rapid. For its administration, the examiner presents a series of pictures to each person. There are four pictures to a page, and each is numbered. The examiner speaks a word describing one of the pictures and asks the individual to point to or say the num ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wechsler Adult Intelligence Scale
The Wechsler Adult Intelligence Scale (WAIS) is an IQ test designed to measure intelligence and cognitive ability in adults and older adolescents. For children between the ages of 6 and 16, Wechsler Intelligence Scale for Children (WISC) is commonly used. The original WAIS (Form I) was published in February 1955 by David Wechsler, Chief Psychologist at Bellevue Hospital (1932–1967) in NYC, as a revision of the Wechsler–Bellevue Intelligence Scale released in 1939. It is currently in its fifth edition (''WAIS-5''), released in 2024 by Pearson. It is the most widely used IQ test, for both adults and older adolescents, in the world. History The WAIS was founded to get to know Wechsler's patients at Bellevue Hospital and on his definition of intelligence, which he defined as "... the global capacity of a person to act purposefully, to think rationally, and to deal effectively with his environment." He believed that intelligence was made up of specific elements that could b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Preterm
Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age, as opposed to full-term delivery at approximately 40 weeks. Extreme preterm is less than 28 weeks, very early preterm birth is between 28 and 32 weeks, early preterm birth occurs between 32 and 34 weeks, late preterm birth is between 34 and 36 weeks' gestation. These babies are also known as premature babies or colloquially preemies (American English) or premmies (Australian English). Symptoms of preterm labor include uterine contractions which occur more often than every ten minutes and/or the leaking of fluid from the vagina before 37 weeks. Premature infants are at greater risk for cerebral palsy, delays in development, hearing problems and problems with their vision. The earlier a baby is born, the greater these risks will be. The cause of spontaneous preterm birth is often not known. Risk factors include diabetes, high blood pressure, multiple gestation (being ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conduct Disorder
Conduct disorder (CD) is a mental disorder diagnosed in childhood or adolescence that presents itself through a repetitive and persistent pattern of behavior that includes theft, lies, physical violence that may lead to destruction, and reckless breaking of rules, in which the basic rights of others or major age-appropriate norms are violated. These behaviors are often referred to as " antisocial behaviors", and is often seen as the precursor to antisocial personality disorder; however, the latter, by definition, cannot be diagnosed until the individual is 18 years old. Conduct disorder may result from parental rejection and neglect and in such cases can be treated with family therapy, as well as behavioral modifications and pharmacotherapy. It may also be caused by environmental lead exposure. Conduct disorder is estimated to affect 51.1 million people globally Signs and symptoms One of the symptoms of conduct disorder is a lower level of fear. Research performed on th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Temporal Lobe Epilepsy
In the field of neurology, temporal lobe epilepsy is an enduring brain disorder that causes unprovoked seizures from the temporal lobe. Temporal lobe epilepsy is the most common type of focal onset epilepsy among adults. Seizure symptoms and behavior distinguish seizures arising from the mesial (medial) temporal lobe from seizures arising from the lateral (neocortical) temporal lobe. Memory and psychiatric comorbidities may occur. Diagnosis relies on electroencephalographic (EEG) and neuroimaging studies. Anticonvulsant medications, epilepsy surgery, and dietary treatments may improve seizure control. Types Under the International League Against Epilepsy (ILAE) 2017 classification of the epilepsies, focal onset epilepsy occurs from seizures arising from a biological neural network within a single cerebral hemisphere. Temporal lobe epilepsy occurs from seizures arising within the temporal lobe. Temporal lobe epilepsy is the most common focal onset epilepsy, and 80% of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
