U-32,802A
U-32,802A is an antipsychotic tranquilizer of the butyrophenone class. It was developed by Daniel Lednicer at Upjohn Pharmaceuticals in the early part of the 1970’s. Whereas related agents are based on a 4-aryl-piperidine central ring system, U-32,802A is an 4-aryl-cyclohexylamine, which might be expected to offer a unique pharmacological profile. Based on the available pharmacological data, U-32,802A was hypothesized to act primarily at the presynaptic organelles for storage of monoamines in a way similar to tetrabenazine Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is sold under the brand names Nitoman and Xenazine among others. On August 15, 2008, the US Food and Drug Administration (FDA) approved the use of tet .... Analogs Cyclohexylamine butyrophenones A large number of cyclohexylamine butyrophenones was reported by Lednicer et al.: # PC12251406 # PC83261250 4-(2-Methoxyphenyl)cyclohex-3-en-1-amine, #PC37529 # Be ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]