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Trichothecene
The trichothecenes are a large family of chemically related mycotoxins. They are produced by various species of ''Fusarium'', ''Myrothecium'', ''Trichoderma''/''Podostroma'', '' Trichothecium'', ''Cephalosporium'', '' Verticimonosporium'', and '' Stachybotrys''. Chemically, trichothecenes are a class of sesquiterpenes. The determining structural features causing the biological activity of trichothecenes are the 12,13-epoxy ring, the presence of hydroxyl or acetyl groups at appropriate positions on the trichothecene nucleus, and the structure and position of the side-chain. They are produced on many different grains such wheat, oats or maize by various ''Fusarium'' species including ''F. graminearum'', ''F. sporotrichioides'', ''F. poae'' and ''F. equiseti''. Some molds that produce trichothecene mycotoxins, for example '' Stachybotrys chartarum'', can grow in damp indoor environments. It has been found that macrocyclic trichothecenes produced by ''S. chartarum'' can become airborn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trichothecenes
The trichothecenes are a large family of chemically related mycotoxins. They are produced by various species of ''Fusarium'', ''Myrothecium'', ''Trichoderma''/''Podostroma'', '' Trichothecium'', ''Cephalosporium'', '' Verticimonosporium'', and '' Stachybotrys''. Chemically, trichothecenes are a class of sesquiterpenes. The determining structural features causing the biological activity of trichothecenes are the 12,13-epoxy ring, the presence of hydroxyl or acetyl groups at appropriate positions on the trichothecene nucleus, and the structure and position of the side-chain. They are produced on many different grains such wheat, oats or maize by various ''Fusarium'' species including ''F. graminearum'', ''F. sporotrichioides'', ''F. poae'' and ''F. equiseti''. Some molds that produce trichothecene mycotoxins, for example '' Stachybotrys chartarum'', can grow in damp indoor environments. It has been found that macrocyclic trichothecenes produced by ''S. chartarum'' can become airborn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T-2 Mycotoxin
T-2 Mycotoxin (pronounced as 'Tee-Two') is a trichothecene mycotoxin. It is a naturally occurring mold byproduct of ''Fusarium'' spp. fungus which is toxic to humans and animals. The clinical condition it causes is ''alimentary toxic aleukia'' and a host of symptoms related to organs as diverse as the skin, airway, and stomach. Ingestion may come from consumption of moldy whole grains. T-2 can be absorbed through human skin. Although no significant systemic effects are expected after dermal contact in normal agricultural or residential environments, local skin effects can not be excluded. Hence, skin contact with T-2 should be limited. History Alimentary toxic aleukia (ATA), a disease which is caused by trichothecenes like T-2 mycotoxin, killed many thousands of USSR citizens in the Orenburg District in the 1940s. It was reported that the mortality rate was 10% of the entire population in that area. During the 1970s it was proposed that the consumption of contaminated food wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nivalenol
Nivalenol (NIV) is a mycotoxin of the trichothecene group. In nature it is mainly found in fungi of the ''Fusarium'' species. The ''Fusarium'' species belongs to the most prevalent mycotoxin producing fungi in the temperate regions of the northern hemisphere, therefore making them a considerable risk for the food crop production industry. The fungi are abundant in various agricultural products (cereal crops) and their further processed products (malt, beer and bread). "The ''Fusarium'' species invade and grow on crops, and may produce nivalenol under moist and cool conditions". The symptoms observed after being affected with nivalenol are "feed refusal, vomiting, gastroenteric and dermal irritation or necrosis and immunological dysfunction", as well as haematotoxicity, resulting in a low leukocyte count. History In the period of 1946-1963 several cases of intoxication due to the ingestion of ''Fusarium'' infected grains (Scrabby grain disease) were reported in Japan, Korea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Podostroma Cornu-damae
, also known as the poison fire coral, is a species of fungus in the family Hypocreaceae. The fruit bodies of the fungus are highly toxic, and have been responsible for several fatalities in Japan. The fungus contains several trichothecene mycotoxins. Taxonomy The species was originally described as ''Hypocrea cornu-damae'' by Narcisse Théophile Patouillard in 1895, and later transferred to the genus ''Podocrea'' in 1905 by Pier Andrea Saccardo. In 1994 Japanese mycologists Tsuguo Hongo and Masana Izawa placed the species in the genus ''Podostroma''. Range The fungus was once thought to be only native to Korea and Japan, but recent discoveries have been made in Indonesia (Java), Papua New Guinea and some parts of Australia. Burt, Jemima and Mounter, Brendan (2021-02-19Deadly fungus, poison fire coral, sighted near Cairns, prompting warning for bushwalkers''ABC News'', 2021-02-19. Description The conidiophores (specialized fungal hyphae that produce conidia) are up to 400&n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycotoxin
A mycotoxin (from the Greek μύκης , "fungus" and τοξίνη , "toxin") is a toxic secondary metabolite produced by organisms of kingdom Fungi and is capable of causing disease and death in both humans and other animals. The term 'mycotoxin' is usually reserved for the toxic chemical products produced by fungi that readily colonize crops. Examples of mycotoxins causing human and animal illness include aflatoxin, citrinin, fumonisins, ochratoxin A, patulin, trichothecenes, zearalenone, and ergot alkaloids such as ergotamine. One mold species may produce many different mycotoxins, and several species may produce the same mycotoxin. Production Most fungi are aerobic (use oxygen) and are found almost everywhere in extremely small quantities due to the diminute size of their spores. They consume organic matter wherever humidity and temperature are sufficient. Where conditions are right, fungi proliferate into colonies and mycotoxin levels become high. The reason for the product ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stachybotrys Chartarum
''Stachybotrys chartarum'' (, ), also known as black mold or toxic black mold, is a species of microfungus that produces its conidia in slime heads. It is sometimes found in soil and grain, but the mold is most often detected in cellulose-rich building materials, such as gypsum-based drywall and wallpaper, from damp or water-damaged buildings. Taxonomy The fungus was originally described scientifically in 1818 by Christian Gottfried Ehrenberg as a member of the genus '' Stilbospora''. His diagnosis emphasized the form of the spores, which he described as minute, sub-opaque, ovate, and agglomerated into subconcentric, water-soluble irregular clusters. He noted that the fungus adheres to paper, sometimes forming circles dotted with black. Stanley Hughes transferred the taxon to '' Stachybotrys'' in 1958. This genus was circumscribed in 1832 by Czech mycologist August Carl Joseph Corda, with ''Stachybotrys atra'' assigned as its type species. The species concept of ''Stachybotrys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fusarium
''Fusarium'' is a large genus of filamentous fungi, part of a group often referred to as hyphomycetes, widely distributed in soil and associated with plants. Most species are harmless saprobes, and are relatively abundant members of the soil microbial community. Some species produce mycotoxins in cereal crops that can affect human and animal health if they enter the food chain. The main toxins produced by these ''Fusarium'' species are fumonisins and trichothecenes. Despite most species apparently being harmless (some existing on the skin as commensal members of the skin flora), some ''Fusarium'' species and subspecific groups are among the most important fungal pathogens of plants and animals. The name of ''Fusarium'' comes from Latin ''fusus'', meaning a spindle. Taxonomy The taxonomy of the genus is complex. A number of different schemes have been used, and up to 1,000 species have been identified at times, with approaches varying between wide and narrow concepts of speci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Satratoxin H
Satratoxin-H, a trichothecene mycotoxin, is a naturally occurring toxin produced by the ascomycetes ''Stachybotrys chartarum'' and ''Podostroma cornu-damae'' which is toxic to humans and animals. The clinical condition it causes is known as ''Stachybotrotoxicosis''. It is related to the mycotoxin T-2, but unlike T-2 has not been reported to have been used as a chemical weapon. Properties Satratoxin-H is almost completely insoluble in water, but is easily soluble in lower alcohols and polar solvents such as ethanol, methanol, 2-propanol, acetone and chloroform. Satratoxin-H is not officially classified as a chemical weapon. Effects Satratoxin-H is extremely versatile. Contact with the solution through ingestion, inhalation, or even prolonged physical contact produces symptoms similar to those listed below. * a rash that becomes a moist dermatitis * nosebleeds * chest pain * pulmonary hemorrhage Pulmonary hemorrhage (or pulmonary haemorrhage) is an acute bleeding fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stachybotrys
''Stachybotrys'' () is a genus of molds, hyphomycetes or asexually reproducing, filamentous fungi, now placed in the family Stachybotryaceae. The genus was erected by August Carl Joseph Corda in 1837. Historically, it was considered closely related to the genus ''Memnoniella'', because the spores are produced in slimy heads rather than in dry chains. Recently, the synonymy of the two genera is generally accepted. Most ''Stachybotrys'' species inhabit materials rich in cellulose. The genus has a widespread distribution and contains about 50 species. The name comes from the Greek words σταχυς ''stakhus'' (ear of grain, stalk, stick; metaphorically, progeny) and βότρυς ''botrus'' (cluster or bunch as in grapes, trusses). The most infamous species, '' S. chartarum'' (previously known as ''S. atra'') and ''S. chlorohalonata'', are known as black mold or toxic black mold in the U.S., and are frequently associated with poor indoor air quality that arises after fungal growt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transfer RNA
Transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length (in eukaryotes), that serves as the physical link between the mRNA and the amino acid sequence of proteins. tRNAs genes from Bacteria are typically shorter (mean = 77.6 bp) than tRNAs from Archaea (mean = 83.1 bp) and eukaryotes (mean = 84.7 bp). The mature tRNA follows an opposite pattern with tRNAs from Bacteria being usually longer (median = 77.6 nt) than tRNAs from Archaea (median = 76.8 nt), with eukaryotes exhibiting the shortest mature tRNAs (median = 74.5 nt). Transfer RNA (tRNA) does this by carrying an amino acid to the protein synthesizing machinery of a cell called the ribosome. Complementation of a 3-nucleotide codon in a messenger RNA (mRNA) by a 3-nucleotide anticodon of the tRNA results in protein synthesis based on the mRNA code. As such, tRNAs are a necessary component of translation, the biological sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ribosome
Ribosomes ( ) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins). The ribosomes and associated molecules are also known as the ''translational apparatus''. Overview The sequence of DNA that encodes the sequence of the amino acids in a protein is transcribed into a messenger RNA chain. Ribosomes bind to messenger RNAs and use their sequences for determining the correct sequence of amino acids to generate a given protein. Amino acids are selected and carried to the ribosome by transfer RNA (tRNA) molecules, which enter the ribosome and bind to the messenger RNA chain via an anti-c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Control Of The Apoptosis Mecanisms
Control may refer to: Basic meanings Economics and business * Control (management), an element of management * Control, an element of management accounting * Comptroller (or controller), a senior financial officer in an organization * Controlling interest, a percentage of voting stock shares sufficient to prevent opposition * Foreign exchange controls, regulations on trade * Internal control, a process to help achieve specific goals typically related to managing risk Mathematics and science * Control (optimal control theory), a variable for steering a controllable system of state variables toward a desired goal * Controlling for a variable in statistics * Scientific control, an experiment in which "confounding variables" are minimised to reduce error * Control variables, variables which are kept constant during an experiment * Biological pest control, a natural method of controlling pests * Control network in geodesy and surveying, a set of reference points of known geospatial coo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
