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TKI may refer to: * Tyrosine kinase inhibitor A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. The proteins are activated by adding a phosph ..., a pharmaceutical drug * McKinney National Airport (FAA LID code), McKinney, Texas, US * Tokeen Seaplane Base (IATA code), Alaska, US * Thomas–Kilmann Conflict Mode Instrument, a conflict style inventory * Turkish Coal Operations Authority (TKİ, Türkiye Kömür İşletmeleri Kurumu) {{disambiguation ...
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Tyrosine Kinase Inhibitor
A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. The proteins are activated by adding a phosphate group to the protein (phosphorylation), a step that TKIs inhibit. TKIs are typically used as anticancer drugs. For example, they have substantially improved outcomes in chronic myelogenous leukemia. They have also been used to treat other diseases, such as idiopathic pulmonary fibrosis. They are also called tyrphostins, the short name for "tyrosine phosphorylation inhibitor", originally coined in a 1988 publication, which was the first description of compounds inhibiting the catalytic activity of the epidermal growth factor receptor (EGFR). The 1988 study was the first demonstration of a systematic search and discovery of small-molecular-weight inhibitors of tyrosine phosphorylation, which do not inhibit protein kinases that phosphor ...
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McKinney National Airport
McKinney National Airport , formerly Collin County Regional Airport at McKinney, is a general aviation airport located in McKinney, Texas, United States, about 30 miles north of downtown Dallas. The airport is a reliever airport for Dallas Love Field and Dallas/Fort Worth International Airport. It is owned by the City of McKinney and is home to many business aircraft, including the aircraft fleets of corporations such as Texas Instruments and Toyota Motor Corporation that are headquartered in nearby cities. It is an air base for PHI Air Medical which provides 24-hour emergency helicopter ambulance service. The only fixed-base operator (FBO) on the field is the city-run McKinney Air Center. There are two flight schools at the airport: ATP and Grayhawk Flight Training. The airport housed Civil Air Patrol Texas Wing 295th Squadron from 2013 to 2014. History In the 1970s, the FAA proposed building the region's third major commercial airport, providing commercial air service to the ...
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Tokeen Seaplane Base
Tokeen Seaplane Base is a public use seaplane base located in Tokeen, in the Prince of Wales-Hyder Census Area in the U.S. state of Alaska. Although most U.S. airports use the same three-letter location identifier for the FAA and IATA, this airport is assigned TKI by the IATA and 57A by the FAA (which assigned TKI to McKinney National Airport in McKinney, Texas). Facilities and aircraft Tokeen Seaplane Base has one seaplane landing area designated NE/SW which measures 6,000 by 400 feet (1,829 x 122 m). For the 12-month period ending December 31, 2006, the airport had 55 aircraft operations, an average of 4 per month: 91% air taxi and 9% general aviation General aviation (GA) is defined by the International Civil Aviation Organization (ICAO) as all civil aviation aircraft operations with the exception of commercial air transport or aerial work, which is defined as specialized aviation services .... See also * List of airports in Alaska References External links ...
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Thomas–Kilmann Conflict Mode Instrument
The Thomas–Kilmann Conflict Mode Instrument (TKI) is a conflict style inventory, which is a tool developed to measure an individual's response to conflict situations. Development A number of conflict style inventories have been in active use since the 1960s. Most of them are based on the managerial grid developed by Robert R. Blake and Jane Mouton in their managerial grid model. The Blake and Mouton model uses two axes: "concern for people" is plotted using the vertical axis and "concern for task" along the horizontal axis. Each axis has a numerical scale of 1 to 9. These axes interact so as to diagram five different styles of management. This grid posits the interaction of task with relationship and shows that according to how people value these, there are five basic ways of interacting with others. In 1974, Kenneth W. Thomas and Ralph H. Kilmann introduced their Thomas–Kilmann Conflict Mode Instrument (Tuxedo NY: Xicom, 1974). Description The Thomas–Kilmann Conflict ...
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