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Trichosanthes Kirilowii
''Trichosanthes kirilowii'' is a flowering plant in the family Cucurbitaceae found particularly in Henan, Shandong, Hebei, Shanxi, and Shaanxi (China). It is one of the 50 fundamental herbs used in traditional Chinese medicine, where it shares the name ''guālóu'' () with the related ''T. rosthornii''. It is known as "Chinese cucumber" and "Chinese snake gourd" in English. Traditional uses The tuber of this plant is known in Mandarin as ''tiān huā fěn'' (). In traditional Chinese medicine it is said to drain heat and generate fluids, clear and drain lung heat, transform phlegm, and moisten lung dryness, and resolve toxicity and expel pus. The fruit of the plant, also referred to in Mandarin as ''guālóu'' (), is said to clear heat and transform phlegm-heat, unbind the chest, reduces abscesses and dissipate nodules. Both forms should be considered safe only for use with professional guidance by someone trained in their use, though this may be an unnecessary extrapolation fro ...
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Maxim
Maxim or Maksim may refer to: Entertainment *Maxim (magazine), ''Maxim'' (magazine), an international men's magazine ** Maxim (Australia), ''Maxim'' (Australia), the Australian edition ** Maxim (India), ''Maxim'' (India), the Indian edition *Maxim Radio, ''Maxim'' magazine's radio channel on Sirius Satellite Radio *''Maxim'', a fictional ship in the manga and anime series ''One Piece'' *Maxim, the hero of the video game ''Lufia II: Rise of the Sinistrals'' and its Video game remake, remake, ''Lufia: Curse of the Sinistrals'' Literature and language *A species of adage, aphorism, or saying that expresses a general morality, moral rule, especially a maxim (philosophy), philosophical maxim *Maxims (Old English poems), ''Maxims'' (Old English poems), examples of gnomic poetry *''Maximes'' (1665–78) of François de La Rochefoucauld (writer), François de La Rochefoucauld (1613–80) Organizations *Mary Maxim, craft and needlework mail-order company in Canada *Maxim Brewery, brewing ...
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Toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacteria, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (biology), cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). Sometimes the word is more or less synonymous with poison#Poisoning, poisoning in everyday usage. A central concept of toxicology is that the effects of a toxicant are Dose (biochemistry), dose-dependent; even water can lead to water intoxication when taken in too high a dose, whereas for even a very toxic substance such as snake venom there is a dose below which there is no detectable toxic effect. Toxicity is species-specific, making cross-species analysis problematic. Newer paradigms and metrics are evolving to bypass animal testing, while maintaining the concept of toxicity endpoints. Etymology In Ancient G ...
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Medicinal Plants
Medicinal plants, also called medicinal herbs, have been discovered and used in traditional medicine practices since prehistoric times. Plants synthesize hundreds of chemical compounds for various functions, including Plant defense against herbivory, defense and protection against insects, fungi, Plant disease resistance, diseases, against parasites and herbivorous mammals. The earliest historical records of herbs are found from the Sumerian civilization, where hundreds of medicinal plants including opium are listed on clay tablets, . The Ebers Papyrus from ancient Egypt, , describes over 850 plant medicines. The Greek physician Pedanius Dioscorides, Dioscorides, who worked in the Roman army, documented over 1000 recipes for medicines using over 600 medicinal plants in , ; this formed the basis of pharmacopoeias for some 1500 years. Drug research sometimes makes use of ethnobotany to search for pharmacologically active substances, and this approach has yielded hundreds of use ...
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Trichosanthes
''Trichosanthes'' is a genus of tropical and subtropical vines. They belong to the cucumber family (Cucurbitaceae), and are closely related to '' Gymnopetalum''. '' Hodgsonia'', formerly included here, is usually considered a well-distinct genus nowadays. The shoots, tendrils, and leaves of some or possibly all species may be eaten as greens, and at least two species ( serpent gourd, ''T. cucumerina'', and pointed gourd, ''T. dioica'') are grown commercially for their fleshy fruits used as vegetables, most popular in South Asia and Southeast Asia. At least two species ('' T. kirilowii'' and '' T. rosthornii'') are grown for use in traditional Chinese medicine, where they are called the name ''gualou'' (). ''Trichosanthes'' is also known as a medicinal as well as poisonous plant in India. The herb has shown an ability to reduce chest congestion by breaking down phlegm and aiding in its removal from the lungs. Selected species * '' Trichosanthes baviensis'' Gagnepain * '' Trich ...
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United States National Agricultural Library
The United States National Agricultural Library (NAL) is one of the world's largest agricultural research libraries, and serves as a national library of the United States and as the library of the United States Department of Agriculture. Located in Beltsville, Maryland, it is one of five national libraries of the United States (along with the Library of Congress, the National Library of Medicine, the National Transportation Library, and the National Library of Education). It is also the coordinator for the Agriculture Network Information Center (AgNIC), a national network of state land-grant institutions and coordinator for the U.S. Department of Agriculture (USDA) field libraries. NAL was established on May 15, 1862, by the signing of the Organic Act by Abraham Lincoln. It served as a departmental library until 1962, when the Secretary of Agriculture officially designated it as the National Agricultural Library. The first librarian, appointed in 1867, was Aaron B. Grosh, ...
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Ricin
Ricin ( ) is a lectin (a carbohydrate-binding protein) and a highly potent toxin produced in the seeds of the castor oil plant, ''Ricinus communis''. The median lethal dose (LD50) of ricin for mice is around 22 micrograms per kilogram of body weight via intraperitoneal injection. Oral exposure to ricin is far less toxic. An estimated lethal oral dose in humans is approximately one milligram per kilogram of body weight. Ricin is a toxalbumin and was first described by Peter Hermann Stillmark, the founder of lectinology. Ricin is chemically similar to Robin (toxin), robin. Biochemistry Ricin is classified as a type 2 ribosome-inactivating protein (RIP). Whereas type 1 RIPs are composed of a single protein chain that possesses catalytic activity, type 2 RIPs, also known as holotoxins, are composed of two different protein chains that form a heterodimeric complex. Type 2 RIPs consist of an A chain that is functionally equivalent to a type 1 RIP, covalently connected by a single ...
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In Vitro
''In vitro'' (meaning ''in glass'', or ''in the glass'') Research, studies are performed with Cell (biology), cells or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates. Studies conducted using components of an organism that have been isolated from their usual biological surroundings permit a more detailed or more convenient analysis than can be done with whole organisms; however, results obtained from ''in vitro'' experiments may not fully or accurately predict the effects on a whole organism. In contrast to ''in vitro'' experiments, ''in vivo'' studies are those conducted in living organisms, including humans, known as clinical trials, and whole plants. Definition ''In vitro'' (Latin language, Latin for "in glass"; often not italicized in English usage) studies are conducted ...
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AIDS Virus
The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, the average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. In most cases, HIV is a sexually transmitted infection and occurs by contact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids. Non-sexual transmission can occur from an infected mother to her infant during pregnancy, during childbirth by exposure to her blood or vaginal fluid, and through breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. Research has shown (for both same-sex and opposite-sex couples) that HIV is not contagious duri ...
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Trichosanthin
Trichosanthin is a ribosome-inactivating protein. It is derived from ''Trichosanthes kirilowii''. It is also an abortifacient An abortifacient ("that which will cause a miscarriage" from Latin: '' abortus'' "miscarriage" and '' faciens'' "making") is a substance that induces abortion. This is a nonspecific term which may refer to any number of substances or medications, .... References External links * Proteins Ribosome-inactivating proteins {{pharmacology-stub ...
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Traditional Chinese Medicine
Traditional Chinese medicine (TCM) is an alternative medicine, alternative medical practice drawn from traditional medicine in China. A large share of its claims are pseudoscientific, with the majority of treatments having no robust evidence of effectiveness or logical mechanism of action. Some TCM ingredients Traditional Chinese medicine#Safety, are known to be toxic and cause disease, including cancer. Medicine in traditional China encompassed a range of sometimes competing health and healing practices, folk beliefs, Scholar-official, literati theory and Confucianism, Confucian philosophy, Chinese herbology, herbal remedies, Chinese food therapy, food, diet, exercise, medical specializations, and schools of thought. TCM as it exists today has been described as a largely 20th century invention. In the early twentieth century, Chinese cultural and political modernizers worked to eliminate traditional practices as backward and unscientific. Traditional practitioners then selec ...
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Flowering Plant
Flowering plants are plants that bear flowers and fruits, and form the clade Angiospermae (). The term angiosperm is derived from the Ancient Greek, Greek words (; 'container, vessel') and (; 'seed'), meaning that the seeds are enclosed within a fruit. The group was formerly called Magnoliophyta. Angiosperms are by far the most diverse group of Embryophyte, land plants with 64 Order (biology), orders, 416 Family (biology), families, approximately 13,000 known Genus, genera and 300,000 known species. They include all forbs (flowering plants without a woody Plant stem, stem), grasses and grass-like plants, a vast majority of broad-leaved trees, shrubs and vines, and most aquatic plants. Angiosperms are distinguished from the other major seed plant clade, the gymnosperms, by having flowers, xylem consisting of vessel elements instead of tracheids, endosperm within their seeds, and fruits that completely envelop the seeds. The ancestors of flowering plants diverged from the commo ...
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Chinese Herbology
Chinese herbology () is the theory of traditional Chinese herbal therapy, which accounts for the majority of treatments in traditional Chinese medicine (TCM). A ''Nature'' editorial described TCM as "fraught with pseudoscience", and said that the most obvious reason why it has not delivered many cures is that the majority of its treatments have no logical mechanism of action. The term herbology is misleading in the sense that, while plant elements are by far the most commonly used substances, animal, human, and mineral products are also used, some of which are poisonous. In the they are referred to as () which means "poison-medicine". Paul U. Unschuld points out that this is similar etymology to the Greek and so he uses the term ''pharmaceutic''. Thus, the term ''medicinal'' (instead of ''herb'') is usually preferred as a translation for (). Research into the effectiveness of traditional Chinese herbal therapy is of poor quality and often tainted by bias, with little or n ...
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