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Tomáš Cihlář
Tomáš Cihlář (born 1967) is a Czech biochemist known for his role in the development of remdesivir. A specialist in virology, Cihlář holds the positions of senior director, biology, and vice-president at American pharmaceutical company Gilead Sciences. As a student, Cihlář assisted fellow biochemist Antonín Holý in developing Viread, the primary drug used to fight HIV infection. Education Cihlář graduated from the University of Chemistry and Technology, Prague, majoring in fermentation chemistry and bioengineering under the tutelage of Jan Páca and Vladimír Jirků. He completed his postgraduate studies at the Institute of Organic Chemistry and Biochemistry of the ASCR under Ivan Rosenberg and Ivan Votruba. In 1994 he obtained the title of Candidate of Sciences and was engaged in the research of antiviral agents under the tutelage of Antonín Holý. That same year, he traveled to the United States for a postdoctoral fellowship with Gilead Sciences, where as research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plzeň
Plzeň (), also known in English and German as Pilsen (), is a city in the Czech Republic. It is the Statutory city (Czech Republic), fourth most populous city in the Czech Republic with about 188,000 inhabitants. It is located about west of Prague, at the confluence of four rivers: Mže, Úhlava, Úslava and Radbuza, together forming the Berounka River. Founded as a royal city in the late 13th century, Plzeň became an important town for trade on routes linking Bohemia with Bavaria. By the 14th century it had grown to be the third largest city in Bohemia. The city was besieged three times during the 15th-century Hussite Wars, when it became a centre of resistance against the Hussites. During the Thirty Years' War in the early 17th century the city was temporarily occupied after the Siege of Plzeň. In the 19th century, the city rapidly industrialised and became home to the Škoda Works, which became one of the most important engineering companies in Austria-Hungary and later ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MERS
Middle East respiratory syndrome (MERS) is a viral respiratory infection caused by '' Middle East respiratory syndrome–related coronavirus'' (MERS-CoV). Symptoms may range from none, to mild, to severe depending on age and risk level. Typical symptoms include fever, cough, diarrhea, and shortness of breath. The disease is typically more severe in those with other health problems. The first case was identified in June 2012 by Egyptian physician Ali Mohamed Zaki at the Dr. Soliman Fakeeh Hospital in Jeddah, Saudi Arabia, and most cases have occurred in the Arabian Peninsula. Over 2,600 cases have been reported as of January 2021, including 45 cases in the year 2020. About 35% of those who are diagnosed with the disease die from it. Larger outbreaks have occurred in South Korea in 2015 and in Saudi Arabia in 2018. MERS-CoV is a virus in the coronavirus family believed to be originally from bats. However, humans are typically infected from camels, either during direct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coronavirus Disease 2019
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2. In January 2020, the disease spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 can vary but often include fever, fatigue, cough, breathing difficulties, loss of smell, and loss of taste. Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms. Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms ( dyspnea, hypoxia, or more than 50% lung involvement on imaging), and 5% develop critical symptoms ( respiratory failure, shock, or multiorgan dysfunction). Older people have a higher risk of developing severe symptoms. Some complications result in death. Some people continue to experience a range of effects ( long COVID) for mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The National Interest
''The National Interest'' (''TNI'') is an American bimonthly international relations magazine edited by American journalist Jacob Heilbrunn and published by the Center for the National Interest, a public policy think tank based in Washington, D.C., that was established by former U.S. President Richard Nixon in 1994 as the Nixon Center for Peace and Freedom. The magazine is associated with the realist school of international studies. History Founded in 1985 by American columnist and neoconservatism advocate Irving Kristol, the magazine was until 2001 edited by Australian academic Owen Harries. In 2001, The National Interest was acquired by The Center for the National Interest, a public policy think tank based in Washington, D.C., that was established by former U.S. President Richard Nixon on January 20, 1994, as the Nixon Center for Peace and Freedom. In 2005, ten editors of ''The National Interest'' resigned due to different viewpoints regarding the magazine's acqu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mladá Fronta DNES
''Mladá fronta Dnes'' (), also known as ''MF Dnes'' or simply ''Dnes'', is a daily newspaper based in the Czech Republic The Czech Republic, also known as Czechia, and historically known as Bohemia, is a landlocked country in Central Europe. The country is bordered by Austria to the south, Germany to the west, Poland to the northeast, and Slovakia to the south .... As of 2016, it is the second-largest Czech newspaper, after the tabloid '' Blesk''. History and profile ''Mladá fronta Dnes'' is owned by Mafra a.s., a subsidiary of the Agrofert group, a company owned by the former Czech Prime Minister Andrej Babiš. Mafra was previously the Czech subsidiary of the German group Rheinisch-Bergische Druckerei - und Verlagsgesellschaft GmbH, the publisher of the '' Rheinische Post'' that bought it from French press group Socpresse in 1994. The newspaper is published in Berliner format. It consists of four sections, one of which contains regional content. Its orientation c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Justia
Justia is an American website specializing in legal information retrieval. It was founded in 2003 by Tim Stanley, formerly of FindLaw, and is one of the largest online databases of legal cases. The company is headquartered in Mountain View, California. The website offers free case law, codes, opinion summaries, and other basic legal texts, with paid services for its attorney directory and webhosting. In 2007, ''The New York Times'' reported that Justia was spending around "$10,000 a month" in order "to copy documents" from the United States Supreme Court and publish them online, to be made available without the public paying fees. Law library research guides often refer to Justia. Duke Law School's law library's research guide notes how it is helpful for PACER. See also * Legal Information Institute by Cornell Law School Cornell Law School is the law school of Cornell University, a private university, private, Ivy League university in Ithaca, New York. One of the five I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reverse-transcriptase Inhibitor
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses. Mechanism of action When HIV infects a cell, reverse transcriptase copies the viral single stranded RNA genome into a double-stranded viral DNA. The viral DNA is then integrated into the host chromosomal DNA, which then allows host cellular processes, such as transcription and translation, to reproduce the virus. RTIs block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stranded viral DNA, thus preventing HIV from multiplying. A similar process occurs with other types of viruses. The hepatitis B virus, for example, carries its genetic material in the form of DNA, and employs an RNA-dependent DNA polymerase to replicate. Some of the same compounds used as RTIs c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Society For Antiviral Research
The International Society for Antiviral Research (ISAR) is a scientific society that focuses on the discovery and clinical application of antiviral agents. It was founded in 1987 to encourage the exchange of information and collaborative research on the development of biological and chemical antiviral agents. ISAR sponsors the International Conference on Antiviral Research (ICAR), held yearly since 1988 when the second ICAR occurred in Williamsburg, Virginia. ISAR also provides scientific information through peer-reviewed scientific journals and administers several international awards. , the president of the society was Luis M Schang and the president-elect was David Durantel. Previously, Johan Neyts was president from 2018-2020, succeeded as president by Kara Carter (2020-2022), and then Katherine Seley-Radtke (2022-2024). Founding The foundation for the International Society for Antiviral Research (ISAR) was laid at meetings held in Rotterdam, Netherlands (April 30 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Prusoff
William Herman Prusoff (June 25, 1920 – April 3, 2011) was an American pharmacologist who was an early innovator in antiviral drugs, developing idoxuridine, the first antiviral agent approved by the FDA, in the 1950s, and co-developing (with Tai-shun Lin) stavudine, one of the earliest AIDS drugs, in the mid-1980s. Scientific career William Prusoff attended the University of Miami. After receiving his undergraduate degree in chemistry, he obtained his PhD from Columbia University and later completed his postdoctoral training in the laboratory of professor Arnold Welch at Case Western Reserve University. After Welch was recruited by Yale to head the Medical School's pharmacology department, Prusoff was invited to join the same department as an assistant professor and was subsequently promoted to the rank of professor. This relationship at Yale would span over the next 58 years, with William Prusoff becoming one of Yale's most well respected scientists and teachers. Pruso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endosome
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of the endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation or can be recycled back to the cell membrane in the endocytic cycle. Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus. Endosomes can be classified as early, sorting, or late depending on their stage post internalization. Endosomes represent a major sorting compartment of the endomembrane system in cells. Function Endosomes provide an environment for material to be sorted before it reaches the degradative lysosome. For example, low-density lipoprotein (LDL) is taken into the cell by binding to the LDL receptor at the cell surface. Upon reaching early endosomes, the LDL dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TLR7
Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the ''TLR7'' gene. Orthologs are found in mammals and birds. It is a member of the toll-like receptor (TLR) family and detects single stranded RNA. Function The TLR family plays an important role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from ''Drosophila'' to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on the human X chromosome. TLR7 recognizes single-stranded RNA in endosomes, which is a common feature of viral genomes which are internalized by macrophages and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an Receptor antagonist, antagonist blocks the action of the agonist, while an inverse agonist causes an action opposite to that of the agonist. Etymology The word originates from the Ancient Greek, Greek word (''agōnistēs''), "contestant; champion; rival" < (''agōn''), "contest, combat; exertion, struggle" < (''agō''), "I lead, lead towards, conduct; drive." Types of agonists Receptor (biochemistry), Receptors can be activated by either endogenous agonists (such as hormones and neurotransmitters) or exogenous agonists (such as medication, drugs), resulting in a biological response. A physiological agonism an ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
