Tiropramide
Tiropramide is the International nonproprietary name of an antispasmodic drug. Synthesis : The acylation of racemic tyrosine (1) with benzoyl chloride gives N,O-dibenzoyl-tyrosine (2). Amide formation with dipropylamine (3) using the mixed anhydride method gives the intermediate (4). Hydrolysis of the Phenols, phenolic ester with sodium hydroxide forms (5), which is alkylated with to produce the ether tiropramide. References

Drugs acting on the gastrointestinal system and metabolism Benzamides Phenol ethers Diethylamino compounds Dipropylamino compounds {{gastrointestinal-drug-stub ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]