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Timi
The Thrombolysis In Myocardial Infarction (TIMI) Study Group, is an academic research organization (ARO) affiliated with Brigham and Women's Hospital and Harvard Medical School with a focus in the field of cardiovascular disease. The group has its headquarters in Boston, Massachusetts. The TIMI Study Group was founded by physician Eugene Braunwald in 1984. Braunwald held the chairmanship until 2010, when he appointed Marc Sabatine to the position. Among the group's most important works is the TIMI Risk Score, which assesses the risk of death and ischemic events in patients with unstable angina (UA) or non-ST elevation myocardial infarction (NSTEMI). TIMI Risk Score calculators In patients with UA/NSTEMI, the TIMI risk score is a prognostication scheme that categorizes a patient's risk of death and ischemic events and provides a basis for therapeutic decision making. TIMI Score Calculation (1 point for each): * Age ≥ 65 years * Known coronary artery disease (CAD) (stenosis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brigham And Women's Hospital
Brigham and Women's Hospital (BWH or The Brigham) is a teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two founding members of Mass General Brigham, the largest healthcare provider in Massachusetts. Giles Boland, MD, serves as the hospital's current president. Brigham and Women's Hospital conducts the second largest hospital-based research program in the world, with an annual research budget of more than $630 million. History File:Bwh-longwood.jpg, 221 Longwood Avenue, formerly the Boston Lying-In Hospital building, part of Brigham and Women's Hospital but separate from the main building at 15–75 Francis Street; view from Longwood Avenue File:Free Hospital for Women.jpg, Former site of the Free Hospital for Women across the street from Olmsted Park. This institution was absorbed into Brigham and Women's Hospital. File:Brigham Circle at d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School
Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the United States. It provides patient care, medical education, and research training through its 15 clinical affiliates and research institutes, including Massachusetts General Hospital (MGH), Boston Children's Hospital, Dana–Farber Cancer Institute, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Mount Auburn Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, Spaulding Rehabilitation Hospital, and others. Harvard Medical School also partners with newer entities such as Harvard Catalyst, Broad Institute , Broad Institute of MIT and Harvard, Harvard Stem Cell Institute, the Center for Primary Care, and Wyss Institute for Biologically Inspired Engineering. History Harvard ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston, Massachusetts
Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeastern United States. It has an area of and a population of 675,647 as of the 2020 United States census, 2020 census, making it the third-largest city in the Northeastern United States after New York City and Philadelphia. The larger Greater Boston metropolitan statistical area has a population of 4.9 million as of 2023, making it the largest metropolitan area in New England and the Metropolitan statistical area, eleventh-largest in the United States. Boston was founded on Shawmut Peninsula in 1630 by English Puritans, Puritan settlers, who named the city after the market town of Boston, Lincolnshire in England. During the American Revolution and American Revolutionary War, Revolutionary War, Boston was home to several seminal events, incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eugene Braunwald
Eugene Braunwald (born August 15, 1929) is an Austrian-born American cardiologist. Early life Braunwald was born to Jewish parents Wilhelm Braunwald and Clara Wallach in Vienna. He obtained his A.B. and M.D. at New York University, then completed his residency in internal medicine at Johns Hopkins School of Medicine. Braunwald was inspired to pursue a career in cardiology after practicing in the Bellevue Cardiology Clinic, under Ludwig Eichna, during his time as a medical student at New York University. He also attended several cardiology courses in Mexico City, at the . He always thought that the Mexican School of Cardiology was above any other. "We have the technology but they have the practice. The best book of cardiology is the patient itself", he always argued. In 1952, Braunwald married Nina Starr, a thoracic surgeon and medical researcher, with whom he had three children. Nina Starr Braunwald died in 1992. Several years later, he married his second wife, Elaine, former ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Unstable Angina
In dynamical systems instability means that some of the outputs or internal states increase with time, without bounds. Not all systems that are not stable are unstable; systems can also be marginally stable or exhibit limit cycle behavior. In structural engineering, a structural beam or column can become unstable when excessive compressive load is applied. Beyond a certain threshold, structural deflections magnify stresses, which in turn increases deflections. This can take the form of buckling or crippling. The general field of study is called structural stability. Atmospheric instability is a major component of all weather systems on Earth. Instability in control systems In the theory of dynamical systems, a state variable in a system is said to be unstable if it evolves without bounds. A system itself is said to be unstable if at least one of its state variables is unstable. In continuous time control theory, a system is unstable if any of the roots of its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NSTEMI
A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. The most common symptom is retrosternal chest pain or discomfort that classically radiates to the left shoulder, arm, or jaw. The pain may occasionally feel like heartburn. This is the dangerous type of acute coronary syndrome. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, feeling tired, and decreased level of consciousness. About 30% of people have atypical symptoms. Women more often present without chest pain and instead have neck pain, arm pain or feel tired. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, cardiogenic shock or cardiac arrest. Most MIs occur due to coronary artery disease. Risk factors include high blood pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acute Coronary Syndrome
Acute coronary syndrome (ACS) is a syndrome due to decreased blood flow in the coronary arteries such that part of the heart muscle is unable to function properly or dies. The most common symptom is centrally located pressure-like chest pain, often radiating to the left shoulder or angle of the jaw, and associated with nausea and sweating. Many people with acute coronary syndromes present with symptoms other than chest pain, particularly women, older people, and people with diabetes mellitus. Acute coronary syndrome is subdivided in three scenarios depending primarily on the presence of electrocardiogram (ECG) changes and blood test results (a change in cardiac biomarkers such as troponin levels): ST elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), or unstable angina. STEMI is characterized by complete blockage of a coronary artery resulting in necrosis of part of the heart muscle indicated by ST elevation on ECG, NSTEMI is chara ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Killip Class
The Killip classification is a system used in individuals with an acute myocardial infarction (heart attack), taking into account physical examination and the development of heart failure in order to predict and stratify their risk of mortality. Individuals with a low Killip class are less likely to die within the first 30 days after their myocardial infarction than individuals with a high Killip class. __TOC__ The study The study was a case series with unblinded, unobjective outcomes, not adjusted for confounding factors, nor validated in an independent set of patients. The setting was the coronary care unit of a university hospital in the USA. 250 patients were included in the study (aged 28 to 94; mean 64, 72% male) with a myocardial infarction. Patients with a cardiac arrest prior to admission were excluded. Patients were ranked by Killip class in the following way: * Killip class I includes individuals with no clinical signs of heart failure. * Killip class II includes indiv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ischemic Heart Diseases
Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue, i.e., hypoxia and microvascular dysfunction. It also implies local hypoxia in a part of a body resulting from constriction (such as vasoconstriction, thrombosis, or embolism). Ischemia causes not only insufficiency of oxygen but also reduced availability of nutrients and inadequate removal of metabolic wastes. Ischemia can be partial (poor perfusion) or total blockage. The inadequate delivery of oxygenated blood to the organs must be resolved either by treating the cause of the inadequate delivery or reducing the oxygen demand of the system that needs it. For example, patients with myocardial ischemia have a decreased blood flow to the heart and are prescribed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
