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ThTP
Thiamine triphosphate (ThTP) is a biomolecule found in most organisms including bacteria, fungi, plants and animals. Chemically, it is the triphosphate derivative (chemistry), derivative of the vitamin thiamine. Function It has been proposed that ThTP has a specific role in nerve excitability, but this has never been confirmed and recent results suggest that ThTP probably plays a role in cell energy metabolism. Low or absent levels of thiamine triphosphate have been found in Leigh's disease. In ''E. coli'', ThTP is accumulated in the presence of glucose during amino acid starvation. On the other hand, suppression of the carbon source leads to the accumulation, of adenosine thiamine triphosphate (AThTP). Metabolism It has been shown that in brain ThTP is synthesized in mitochondria by a chemiosmotic mechanism, perhaps similar to ATP synthase. In mammals, ThTP is hydrolyzed to thiamine pyrophosphate (ThDP) by a specific thiamine-triphosphatase. It can also be converted into ThD ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thiamine
Thiamine, also known as thiamin and vitamin B1, is a vitamin – an Nutrient#Micronutrients, essential micronutrient for humans and animals. It is found in food and commercially synthesized to be a dietary supplement or medication. Phosphorylated forms of thiamine are required for some Metabolism, metabolic reactions, including the breakdown of Carbohydrate metabolism, glucose and amino acids. Food sources of thiamine include whole grains, legumes, and some meats and fish. Refined grain, Grain processing removes much of the vitamin content, so in many countries cereals and flours are food fortification, enriched with thiamine. Supplements and medications are available to treat and prevent thiamine deficiency and the disorders that result from it such as Thiamine deficiency#Dry beriberi, beriberi and Wernicke encephalopathy. They are also used to treat maple syrup urine disease and Leigh syndrome. Supplements and medications are typically taken Route of administration#Oral ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
