|
Tadamitsu Kishimoto
is a Japanese immunologist known for research on IgM and cytokines, most famously, interleukin 6. He did postdoctoral work under Kimishige Ishizaka, the discoverer of IgE at Johns Hopkins University. He is listed by the Institute for Scientific Information (ISI) as a highly cited biologist and he is also in the top ten of h-index of living biologists. Life Tadamitsu Kishimoto, who was born in Osaka in 1939, was President of Osaka University from 1997 to 2003 and a Member, Council for Science and Technology Policy, Cabinet office from 2004 to 2006. He is now Professor, Graduate School of Frontier Biosciences, Osaka University. He was Dean, Professor and Chairman of Department of Medicine at Osaka University Medical School from which he graduated in 1964.http://www.japanprize.jp/en/prize_prof_2011_kishimoto.html, The Japan Prize Foundation He is currently Japan's leading scientist in the field of life science, specifically in immunology and has made fundamental contributions to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tondabayashi, Osaka
is a city located in Osaka Prefecture, Japan. , the city had an estimated population of 108,803, in 51,632 households and a population density of 1200 persons per km2. The total area of the city is . Geography Tondabayashi is located in the southeastern part of Osaka Prefecture.The northeastern part of the city is flat, and the Ishikawa River passes through the town. The southern part of the city is hilly, rising gradually to the Kongō Range and Katsuragi Mountains. Neighboring municipalities Osaka Prefecture * Chihayaakasaka * Habikino * Kawachinagano * Kanan * Ōsakasayama *Sakai * Taishi Climate Tondabayashi has a Humid subtropical climate (Köppen ''Cfa'') characterized by warm summers and cool winters with light to no snowfall. The average annual temperature in Tondabayashi is 14.2 °C. The average annual rainfall is 1475 mm with September as the wettest month. The temperatures are highest on average in August, at around 26.3 °C, and lowest in January, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
H-index
The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or scholar. The ''h''-index correlates with success indicators such as winning the Nobel Prize, being accepted for research fellowships and holding positions at top universities. The index is based on the set of the scientist's most cited papers and the number of citations that they have received in other publications. The index has more recently been applied to the productivity and impact of a scholarly journal as well as a group of scientists, such as a department or university or country. The index was suggested in 2005 by Jorge E. Hirsch, a physicist at UC San Diego, as a tool for determining theoretical physicists' relative quality and is sometimes called the Hirsch index or Hirsch number. Hirsch intended the ''h''-index to address the main disadvantages of other bibliometric indicators. The total number of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatocyte Stimulating Factor
A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: * Protein synthesis * Protein storage * Transformation of carbohydrates * Synthesis of cholesterol, bile salts and phospholipids * Detoxification, modification, and excretion of exogenous and endogenous substances * Initiation of formation and secretion of bile Structure The typical hepatocyte is cubical with sides of 20-30 μm, (in comparison, a human hair has a diameter of 17 to 180 μm).The diameter of human hair ranges from 17 to 181 μm. The typical volume of a hepatocyte is 3.4 x 10−9 cm3. Smooth endoplasmic reticulum is abundant in hepatocytes, in contrast to most other cell types. Microanatomy Hepatocytes display an eosinophilic cytoplasm, reflecting numerous mitochondria, and basophilic stippling due to large amounts of rough endoplasmic reticulum and free ribosomes. Brown lipofuscin granules are also observed (with in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crohn's Disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea, fever, abdominal distension, and weight loss. Complications outside of the gastrointestinal tract may include anemia, skin rashes, arthritis, uveitis, inflammation of the eye, and fatigue (medical), fatigue. The skin rashes may be due to infections, as well as pyoderma gangrenosum or erythema nodosum. Bowel obstruction may occur as a complication of chronic inflammation, and those with the disease are at greater risk of colon cancer and small bowel cancer. Although the precise causes of Crohn's disease (CD) are unknown, it is believed to be caused by a combination of environmental, Immunity (medical), immune, and bacterial factors in genetically susceptible individuals. It results in a Immune-mediated inflammatory diseases, chronic inflammatory disorder, in which the body's immune system defends the gastrointesti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multiple Myeloma
Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibody, antibodies. Often, no symptoms are noticed initially. As it progresses, bone pain, anemia, Kidney failure, renal insufficiency, and infections may occur. Complications may include hypercalcemia and amyloidosis. The cause of multiple myeloma is unknown. Risk factors include obesity, radiation exposure, family history, age and certain chemicals. There is an increased risk of multiple myeloma in certain occupations. This is due to the occupational exposure to aromatic hydrocarbon solvents having a role in causation of multiple myeloma. Multiple myeloma is the result of a multi-step malignant transformation, and almost universally originates from the pre-malignant stage monoclonal gammopathy of undetermined significance (MGUS). As MGUS evolves into MM, another pre-stage of the disease is reached, known as Smouldering ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiac Myxoma
A myxoma is a rare benign tumor of the heart. Myxomata are the most common primary cardiac tumor in adults, and are most commonly found within the left atrium near the valve of the fossa ovalis. Myxoma may also develop in the other heart chambers. The tumor is derived from multipotent mesenchymal cells. Cardiac myxoma can affect adults between 30 and 60 years of age. Signs and symptoms Symptoms may occur at any time, but most often they accompany a change of body position. Pedunculated myxomata can have a "wrecking ball effect", as they lead to stasis and may eventually embolize themselves. Symptoms may include: * Shortness of breath with activity * Platypnea – Difficulty breathing in the upright position with relief in the supine position * Paroxysmal nocturnal dyspnea – Breathing difficulty when asleep * Dizziness * Fainting * Palpitations – Sensation of feeling your heart beat * Chest pain or tightness * Sudden Death (In which case the disease is an autopsy finding) Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
STAT3
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the ''STAT3'' gene. It is a member of the STAT protein family. Function STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or heterodimers, and translocates to the cell nucleus where it acts as a transcription activators, transcription activator. Specifically, STAT3 becomes activated after phosphorylation of tyrosine 705 in response to such ligands as interferons, epidermal growth factor (EGF), Interleukin 5, interleukin (IL-)5 and Interleukin 6, IL-6. Additionally, activation of STAT3 may occur via phosphorylation of serine 727 by mitogen-activated protein kinases (MAPK) and through Src (gene), c-src non-receptor tyrosine kinase. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NF-IL-6
CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the ''CEBPB'' gene. Function The protein encoded by this intronless gene is a bZIP transcription factor that can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. CEBP-beta is critical for normal macrophage functioning, an important immune cell sub-type; mice unable to express CEBP-beta have macrophages that cannot differentiate (specialize) and thus are unable to perform all their biological functions—inclu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T Cell
T cells (also known as T lymphocytes) are an important part of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface receptor, cell surface. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate to the thymus gland to develop (or mature). T cells derive their name from the thymus. After migration to the thymus, the precursor cells mature into several distinct types of T cells. T cell differentiation also continues after they have left the thymus. Groups of specific, differentiated T cell subtypes have a variety of important functions in controlling and shaping the immune response. One of these functions is immune-mediated cell death, and it is carried out by two major subtypes: Cytotoxic T cell, CD8+ "killer" (cytotoxic) and T helper cell, CD4+ "helper" T cells. (These are named for the presen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Academy Of Sciences Leopoldina
The German National Academy of Sciences Leopoldina (), in short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded on 1 January 1652, based on academic models in Italy, it was originally named the ''Academia Naturae Curiosorum'' until 1687 when Leopold I, Holy Roman Emperor, Emperor Leopold I raised it to an academy and named it after himself. It was since known under the German name ''Deutsche Akademie der Naturforscher Leopoldina'' until 2007, when it was declared to be Germany's National Academy of Sciences. It is the oldest continuously operating academy of natural sciences worldwide. History ' The Leopoldina was founded in the imperial city of Schweinfurt on 1 January 1652 under the Latin name sometimes translated into English as "Academy of the Curious as to Nature." It was founded by four local physicians – Johann Laurentius Bausch, the first president of the society, Johann Michael Fehr, Georg Balthasar Metzger, and Georg Baltha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crafoord Award
The Crafoord Prize () is an annual science prize established in 1980 by Holger Crafoord, a Swedish industrialist, and his wife Anna-Greta Crafoord following a donation to the Royal Swedish Academy of Sciences. It is awarded jointly by the Academy and the Crafoord Foundation in Lund, with the former selecting the laureates. The Prize is awarded in four categories: mathematics and astronomy, geosciences, biosciences (with an emphasis on ecology) and polyarthritis, the final one because Holger suffered from severe rheumatoid arthritis in his later years. The disciplines for which the Crafoord Prize is awarded are chosen so as to complement the Nobel Prizes. Only one award is given each year, according to a rotating scheme – astronomy and mathematics, then geosciences, then biosciences. Since 2012, the prizes in astronomy and mathematics are separate and awarded at the same time; prior to this, the disciplines alternated every cycle. A Crafoord Prize in polyarthritis is only a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA), formerly known as juvenile rheumatoid arthritis (JRA), is the most common chronic rheumatic disease of childhood, affecting approximately 3.8 to 400 out of 100,000 children. ''Juvenile'', in this context, refers to disease onset before 16 years of age, while ''idiopathic'' refers to a condition with no defined cause, and ''arthritis'' is inflammation within the joint. JIA is an autoimmune, noninfective, inflammatory joint disease, the cause of which remains poorly understood. It is characterised by chronic joint inflammation. JIA is a subset of childhood arthritis, but unlike other, more transient forms of childhood arthritis, JIA persists for at least six weeks, and in some children is a lifelong condition. It differs significantly from forms of arthritis commonly seen in adults (osteoarthritis, rheumatoid arthritis), in terms of cause, disease associations, and prognosis. The prognosis for children with JIA has improved dramatically over re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
