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TNO Intestinal Model
TNO (gastro-) Intestinal Models (“TIM”) is a system of models mimicking the digestive tract. The system was developed by TNO, the Netherlands Organisation for Applied Scientific Research. The models are dynamic computer controlled multi-compartmental systems with adjustable parameters for the physiological conditions of the stomach and intestine. Temperature, peristalsis, bile secretion, secretion of saliva, stomach and pancreas enzymes are all fully adjustable. The TIM systems are being used to study the behavior of oral products during transit through the stomach, the small intestine and large intestine. Commonly performed studies concern the digestibility of food and food components, the bioaccessibility for absorption of pharmaceutical compounds, proteins, fat, minerals and (water- and fat-soluble) vitamins. There are different models for the stomach and small intestine (TIM-1 and Tiny-TIM) and a model simulating the physiological conditions of the colon (TIM-2). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Netherlands Organisation For Applied Scientific Research
The Netherlands Organisation for Applied Scientific Research (, abbreviated TNO, literally "Dutch Organisation for Applied Scientific Research") is an independent statutory research organisation in the Netherlands that focuses on applied science. It conducts contract research, offers specialist consulting services, and grants licenses for patents and specialist software. TNO also sets up new companies to market innovations. Background TNO was established by law in 1932 to support companies and governments. TNO also held 10% of the Austrian research center Joanneum Research from 2004 to 2014. Model The work of TNO is focused on the so-called Top Sectors, and social issues relevant to Europe. The Early Research Programmes and Shared Innovation Programmes are always funded in part with public funds. Research results are further developed and applied in contract research, which is fully funded by TNO's customers. Projects * TROPOMI: A satellite instrument that carries out measu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Large Intestine
The large intestine, also known as the large bowel, is the last part of the gastrointestinal tract and of the Digestion, digestive system in tetrapods. Water is absorbed here and the remaining waste material is stored in the rectum as feces before being removed by defecation. The Colon (anatomy), colon (progressing from the ascending colon to the transverse colon, transverse, the descending colon, descending and finally the sigmoid colon) is the longest portion of the large intestine, and the terms "large intestine" and "colon" are often used interchangeably, but most sources define the large intestine as the combination of the cecum, colon, rectum, and anal canal. Some other sources exclude the anal canal. In humans, the large intestine begins in the right iliac region of the pelvis, just at or below the waist, where it is joined to the end of the small intestine at the cecum, via the ileocecal valve. It then continues as the colon ascending colon, ascending the abdomen, across t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Intestine
The small intestine or small bowel is an organ (anatomy), organ in the human gastrointestinal tract, gastrointestinal tract where most of the #Absorption, absorption of nutrients from food takes place. It lies between the stomach and large intestine, and receives bile and pancreatic juice through the pancreatic duct to aid in digestion. The small intestine is about long and folds many times to fit in the abdomen. Although it is longer than the large intestine, it is called the small intestine because it is narrower in diameter. The small intestine has three distinct regions – the duodenum, jejunum, and ileum. The duodenum, the shortest, is where preparation for absorption through small finger-like protrusions called intestinal villus, intestinal villi begins. The jejunum is specialized for the absorption through its lining by enterocytes: small nutrient particles which have been previously digested by enzymes in the duodenum. The main function of the ileum is to absorb vitami ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microbiome
A microbiome () is the community of microorganisms that can usually be found living together in any given habitat. It was defined more precisely in 1988 by Whipps ''et al.'' as "a characteristic microbial community occupying a reasonably well-defined habitat which has distinct physio-chemical properties. The term thus not only refers to the microorganisms involved but also encompasses their theatre of activity". In 2020, an international panel of experts published the outcome of their discussions on the definition of the microbiome. They proposed a definition of the microbiome based on a revival of the "compact, clear, and comprehensive description of the term" as originally provided by Whipps ''et al.'', but supplemented with two explanatory paragraphs, the #First explanatory paragraph, first pronouncing the dynamic character of the microbiome, and the #Second explanatory paragraph, second clearly separating the term ''microbiota'' from the term ''microbiome''. Modified text ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Digestive System
The human digestive system consists of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver, and gallbladder). Digestion involves the breakdown of food into smaller and smaller components, until they can be absorbed and assimilated into the body. The process of digestion has three stages: the cephalic phase, the gastric phase, and the intestinal phase. The first stage, the cephalic phase of digestion, begins with secretions from gastric glands in response to the sight and smell of food, and continues in the human mouth, mouth with the mechanical breakdown of food by chewing, and the chemical breakdown by digestive enzymes in the saliva. Saliva contains amylase, and lingual lipase, secreted by the salivary glands, and serous glands on the tongue. Chewing mixes the food with saliva to produce a Bolus (digestion), bolus to be Swallowing, swallowed down the esophagus to enter the stomach. The second stage, the gastric phase ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Discovery
In the fields of medicine, biotechnology, and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin. More recently, chemical libraries of synthetic small molecules, natural products, or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology. After sequencing of the human genome allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease-modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy. Modern drug discovery i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
