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Sodium Butyrate
Sodium butyrate is a compound with formula Na(C3H7COO). It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expression. As such, it can be used in lab to bring about any of these effects. Specifically, butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene in chromatin structure and function. Inhibition of HDAC activity is estimated to affect the expression of only 2% of mammalian genes. In the lab, sodium butyrate is usually found as a white, water-soluble, crystalline solid. The chemical is notable for having a very strong, unpleasant smell that lingers. When working with sodium butyrate, gloves, eye protection and respiratory masks are advised for safety purpos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Compound (chemistry)
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken and/or new bonds formed. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, using the stan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |