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Sandoz
Sandoz Group AG is a Swiss company that focuses on generic pharmaceuticals and biosimilars. Prior to October 2023, it was part of a division of Novartis that was established in 2003, when Novartis united all of its generics businesses under the name Sandoz. Before this, the company existed as an independent pharmaceutical manufacturer until 1996, when it was merged with Ciba-Geigy to form Novartis. Prior to the merger, it specialized in medicines used in organ transplants, such as Sandimmune, and various antipsychotics and migraine medicines. Its headquarters were in Holzkirchen, Germany and after the spin-off from Novartis, the headquarters moved to Basel, Switzerland, with most of global functions operating from Holzkichen in Germany, Prague in Czechia, and Barcelona in Spain. Sandoz is the global leader in generic pharmaceuticals and biosimilars. History 1886–1995: Formation and initial growth The company was founded in 1886 by Alfred Kern (1850–1893) and Edouard S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Novartis
Novartis AG is a Swiss multinational corporation, multinational pharmaceutical company, pharmaceutical corporation based in Basel, Switzerland. Novartis is one of the largest pharmaceutical companies in the world and was the eighth largest by revenue in 2024. Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren; sold to GlaxoSmithKline in 2015 deal), carbamazepine (Tegretol), valsartan (Diovan), imatinib mesylate (Gleevec/Glivec), cyclosporine (Neoral/Sandimmune), letrozole (Femara), methylphenidate (Ritalin; produced by Sandoz since 2023), terbinafine (Lamisil), deferasirox (Exjade), and others. Novartis was formed in 1996 by the merger of Ciba-Geigy and Sandoz. It was considered the largest corporate merger in history during that time. The pharmaceutical and agrochemical divisions of both companies formed Novartis as an independent entity. The name Novartis was based on the Latin terms, ''novae artes'' (new skills). After the merger, other Ciba-Geigy and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ciba-Geigy
Novartis AG is a Swiss multinational pharmaceutical corporation based in Basel, Switzerland. Novartis is one of the largest pharmaceutical companies in the world and was the eighth largest by revenue in 2024. Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren; sold to GlaxoSmithKline in 2015 deal), carbamazepine (Tegretol), valsartan (Diovan), imatinib mesylate (Gleevec/Glivec), cyclosporine (Neoral/Sandimmune), letrozole (Femara), methylphenidate (Ritalin; produced by Sandoz since 2023), terbinafine (Lamisil), deferasirox (Exjade), and others. Novartis was formed in 1996 by the merger of Ciba-Geigy and Sandoz. It was considered the largest corporate merger in history during that time. The pharmaceutical and agrochemical divisions of both companies formed Novartis as an independent entity. The name Novartis was based on the Latin terms, ''novae artes'' (new skills). After the merger, other Ciba-Geigy and Sandoz businesses were sold, or, like Ci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthur Stoll
Arthur Stoll (8 January 1887 – 13 January 1971) was a Swiss biochemist. Education and career The son of a teacher and school headmaster, he studied chemistry at the ETH Zurich, with a PhD in 1911, where he studied with Richard Willstätter. In 1912, he became a research assistant at the Kaiser Wilhelm Institute for Chemistry in Berlin, with Richard Willstätter, with whom he explored important insights on the importance of chlorophyll in carbon assimilation. In 1917, he was appointed professor of chemistry at the Ludwig Maximilian University of Munich. In the same year, he was hired as head of the pharmaceutical department of the Sandoz chemical factory in Basel. In this company, he was president from 1949 to 1956, Director from 1964 he held the office of President of the Board. Together with Sandoz employees, he developed a range of methods for producing drugs. Thus, he developed the first isolation of ergot alkaloids (as ergotamine and ergobasine) and cardiac glycosides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Hofmann
Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann's team also isolated, named and synthesized the principal psychedelic mushroom compounds psilocybin and psilocin. He authored more than 100 scientific articles and numerous books, including ''LSD: Mein Sorgenkind'' (''LSD: My Problem Child''). In 2007, he shared first place with Tim Berners-Lee on a list of the 100 greatest living geniuses published by ''The Daily Telegraph'' newspaper. Early life and education Albert Hofmann was born in Baden, Switzerland, on 11 January 1906. He was the first of four children to factory toolmaker Adolf Hofmann and Elisabeth ( Schenk) and was baptized Protestant. When his father became ill, Hofmann obtained a position as a commercial apprentice in concurrence with his studies. Owing to his father's low income, Albert's godfather paid for his e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sandimmune
Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, eczema, and in organ transplants to prevent rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes). Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however, ciclosporin does not appear to cause birth defects. Ciclosporin is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MKUltra
MKUltra was an illegal human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA) to develop procedures and identify drugs that could be used during interrogations to weaken individuals and force confessions through brainwashing and psychological torture. The term MKUltra is a CIA cryptonym: "MK" is an arbitrary prefix standing for the Office of Technical Service and "Ultra" is an arbitrary word out of a dictionary used to name this project. The program has been widely condemned as a violation of individual rights and an example of the CIA's abuse of power, with critics highlighting its disregard for consent and its corrosive impact on democratic principles. Project MKUltra began in 1953 and was halted in 1973. MKUltra used numerous methods to manipulate its subjects' mental states and brain functions, such as the covert administration of high doses of psychoactive drugs (especially LSD) and other chemicals without the subjects' c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antipsychotic
Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of Psychiatric medication, psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders. They are also the mainstay, together with mood stabilizers, in the treatment of bipolar disorder. Moreover, they are also used as adjuncts in the treatment of Treatment-resistant depression, treatment-resistant major depressive disorder. The use of antipsychotics may result in many unwanted side effects such as Extrapyramidal symptoms, involuntary movement disorders, gynecomastia, impotence, weight gain and metabolic syndrome. Long-term use can produce List of long term side effects of antipsychotics, adverse effects such as tardive dyskinesia, tardive dystonia, Akathisia, tardive akathisia, and brain tissue volume reduction. The long term use of antipsychotics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Generic Drug
A generic drug is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents. Generic drugs are allowed for sale after the patents on the original drugs expire. Because the active chemical substance is the same, the medical profile of generics is equivalent in performance compared to their performance at the time when they were patented drugs. A generic drug has the same active pharmaceutical ingredient (API) as the original, but it may differ in some characteristics such as the manufacturing process, formulation, excipients, color, taste, and packaging. Although they may not be associated with a particular company, generic drugs are usually subject to government regulations in the countries in which they are dispensed. They are labeled with the name of the manufacturer and a generic non-proprietary name such as the United States Adopted Name (USAN) or International Nonproprietary Name (INN) of the drug. A generic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Timothy Leary
Timothy Francis Leary (October 22, 1920 – May 31, 1996) was an American psychologist and author known for his strong advocacy of psychedelic drugs. Evaluations of Leary are polarized, ranging from "bold oracle" to "publicity hound". According to poet Allen Ginsberg, he was "a hero of American consciousness", while writer Tom Robbins called him a "brave neuronaut". President Richard Nixon disagreed, calling Leary "the most dangerous man in America". During the 1960s and 1970s, at the height of the counterculture movement, Leary was arrested 36 times. As a clinical psychologist at Harvard University, Leary founded the Harvard Psilocybin Project after a revealing experience with magic mushrooms he had in Mexico in 1960. For two years, he tested psilocybin's therapeutic effects, in the Concord Prison Experiment and the Marsh Chapel Experiment. He also experimented with lysergic acid diethylamide (LSD), which was also legal in the U.S. at the time. Other Harvard faculty que ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ergotamine
Ergotamine, sold under the brand name Ergomar among others, is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. It is structurally similar to several neurotransmitters, and it acts as a vasoconstrictor. It is used for acute migraines, sometimes with caffeine as the combination ergotamine/caffeine. The drug is a non-selective modulator or agonist of serotonin receptors and other receptors. It is peripherally selective and crosses into the brain in minimal amounts. Medicinal use of ergot fungus began in the 16th century, for the induction of childbirth; but dosage uncertainty discouraged its use. It has been used to prevent post-partum hemorrhage (bleeding after childbirth). It was first isolated from the ergot fungus by Arthur Stoll, at Sandoz in 1918, and was marketed as Gynergen in 1921. Medical uses Ergotamine is indicated as therapy to abort or prevent vascular headache. Available ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Holzkirchen, Upper Bavaria
Holzkirchen is a market town in Bavaria, Germany. With a population of over 16,000 (2008) it is the largest town in the Miesbach district. Holzkirchen is located on the Alpenvorland in the county of Miesbach. History Holzkirchen was established as a Markt in the 13th century. Holzkirchen was the location of one of the main transmitting stations for Radio Free Europe. Transmissions started in 1951 and provided the people of Eastern Europe with news from Western Europe. The transmitters had a strength of up to 135 Kilowatts and was upgraded to 150 Kilowatts in 1967. The relay transmitters were decommissioned in 1990. Final decommissioning of the Holzkirchen array was in 2004. There were claims that the high-powered transmissions caused illnesses locally . There were also claims that it was so strong that locals could hear the radio programmes through their faucets . Subsequent to the relocation of RFE studios from Munich to Prague, the medium wave transmitter was shut down in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basel
Basel ( ; ), also known as Basle ( ), ; ; ; . is a city in northwestern Switzerland on the river Rhine (at the transition from the High Rhine, High to the Upper Rhine). Basel is Switzerland's List of cities in Switzerland, third-most-populous city (after Zurich and Geneva), with 177,595 inhabitants within the city municipality limits. The official language of Basel is Swiss Standard German and the main spoken language is the local Basel German dialect. Basel is commonly considered to be the cultural capital of Switzerland and the city is famous for its many Museums in Basel, museums, including the Kunstmuseum Basel, Kunstmuseum, which is the first collection of art accessible to the public in the world (1661) and the largest museum of Swiss art, art in Switzerland, the Fondation Beyeler (located in Riehen), the Museum Tinguely and the Museum of Contemporary Art (Basel), Museum of Contemporary Art, which is the first public museum of contemporary art in Europe. Forty museums ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
