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SP-70
SP7 may refer to : * Sp7 transcription factor, a human gene * 2771 Polzunov (1978 SP7), a Main-belt Asteroid discovered on September 26, 1978 * S.A.R.A. SP7, a chassis of a racing car used at the 1928 24 Hours of Le Mans {{Letter-number combination disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sp7 Transcription Factor
Transcription factor Sp7, also called Osterix (Osx), is a protein that in humans is encoded by the ''SP7'' gene. It is a member of the Sp family of Zinc finger transcription factor, zinc-finger transcription factors It is highly conserved among bone-forming vertebrate species It plays a major role, along with RUNX2, Runx2 and DLX5, ''Dlx5'' in driving the differentiation of mesenchymal precursor cells into osteoblasts and eventually osteocytes. Sp7 also plays a regulatory role by inhibiting chondrocyte differentiation maintaining the balance between differentiation of mesenchymal precursor cells into ossified bone or cartilage. Mutations of this gene have been associated with multiple dysfunctional bone phenotypes in vertebrates. During development, a mouse embryo model with Sp7 expression knocked out had no formation of bone tissue. Through the use of GWAS studies, the Sp7 locus in humans has been strongly associated with bone mass density. In addition there is significant genet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2771 Polzunov
__NOTOC__ The year 771 ( DCCLXXI) was a common year starting on Tuesday of the Julian calendar. The denomination 771 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Europe * December 4 – King Carloman I, youngest son of Pepin III ("the Short"), dies (of a severe nosebleed, according to one source)"Cathwulf, Kingship, and the Royal Abbey of Saint-Denis", by Joanna Story, ''Speculum'' at the Villa of Samoussy, leaving his brother Charlemagne sole ruler of the now reunified Frankish Kingdom. Gerberga, the widow of Carloman, flees with her two sons to the court of King Desiderius of the Lombards, at Pavia. * Charlemagne repudiates his Lombard wife Desiderata, daughter of Desiderius, after one year of marriage. He marries the 13-year-old Swabian girl Hildegard, who will bear him nine children. Desiderius, furious at Charlemagne, plans a punitive cam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
