Rudolf Signer
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Rudolf Signer
Rudolf Signer (17 March 1903, Herisau, Switzerland – 1 December 1990, Gümlingen, Switzerland) contributed to the discovery of the DNA double helix. He was a Professor for organic chemistry at the University of Bern from 1935 until 1972. Education Signer was the son of Jakob Signer, a chemical scientist working in the textile industry, and his wife Dorothea Agnes Scherrer. Rudolf Signer went to high school in St. Gallen and matriculated at the ETH Zurich in 1921 to study chemistry, initially in order to become a teacher. 1927 he graduated with his doctorate under the supervision of Hermann Staudinger. Already 1926 he had become ''Wissenschaftlicher Assistent'' at the University of Fribourg, where he qualified as a professor with a Habilitation. Career Signer spent 1932–1933 in Uppsala and Manchester on a Rockefeller-scholarship. He became a non-tenured professor for general and inorganic chemistry at the University of Bern in 1935 and was tenured in 1939. He went on ...
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Herisau
Herisau is a municipality and the capital of the canton of Appenzell Ausserrhoden in Switzerland. It is the seat of the canton's government and parliament; the judicial authorities are situated in Trogen. The central hamlet and the houses around the central square, the Protestant church of 1580, the houses ''Wetter'' and ''zur Rose'' (both 1737), the hamlet ''Schwänberg'' and the government building with the state archive are listed as heritage sites of national significance.Swiss inventory of cultural property of national and regional significance (1995), p. 55. Together with other Alpine towns Herisau engages in the Alpine Town of the Year Association for the implementation of the Alpine Convention to achieve sustainable development in the Alpine Arc. Herisau was awarded Alpine Town of the Year 2003. History Herisau was first mentioned in 837 as ''Herinisauva'', and its church is mentioned in 907. In 1084 Herisau was destroyed as part of battles around the monastery in St. ...
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Inorganic Chemistry
Inorganic chemistry deals with synthesis and behavior of inorganic and organometallic compounds. This field covers chemical compounds that are not carbon-based, which are the subjects of organic chemistry. The distinction between the two disciplines is far from absolute, as there is much overlap in the subdiscipline of organometallic chemistry. It has applications in every aspect of the chemical industry, including catalysis, materials science, pigments, surfactants, coatings, medications, fuels, and agriculture. Key concepts Many inorganic compounds are ionic compounds, consisting of cations and anions joined by ionic bonding. Examples of salts (which are ionic compounds) are magnesium chloride MgCl2, which consists of magnesium cations Mg2+ and chloride anions Cl−; or sodium oxide Na2O, which consists of sodium cations Na+ and oxide anions O2−. In any salt, the proportions of the ions are such that the electric charges cancel out, so that the bulk compound is e ...
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1903 Births
Nineteen or 19 may refer to: * 19 (number), the natural number following 18 and preceding 20 * one of the years 19 BC, AD 19, 1919, 2019 Films * ''19'' (film), a 2001 Japanese film * ''Nineteen'' (film), a 1987 science fiction film Music * 19 (band), a Japanese pop music duo Albums * ''19'' (Adele album), 2008 * ''19'', a 2003 album by Alsou * ''19'', a 2006 album by Evan Yo * ''19'', a 2018 album by MHD * ''19'', one half of the double album ''63/19'' by Kool A.D. * ''Number Nineteen'', a 1971 album by American jazz pianist Mal Waldron * ''XIX'' (EP), a 2019 EP by 1the9 Songs * "19" (song), a 1985 song by British musician Paul Hardcastle. * "Nineteen", a song by Bad4Good from the 1992 album '' Refugee'' * "Nineteen", a song by Karma to Burn from the 2001 album ''Almost Heathen''. * "Nineteen" (song), a 2007 song by American singer Billy Ray Cyrus. * "Nineteen", a song by Tegan and Sara from the 2007 album '' The Con''. * "XIX" (song), a 2014 song by Slipknot. ...
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King's College, London
King's College London (informally King's or KCL) is a public research university located in London, England. King's was established by royal charter in 1829 under the patronage of King George IV and the Duke of Wellington. In 1836, King's became one of the two founding colleges of the University of London. It is one of the oldest university-level institutions in England. In the late 20th century, King's grew through a series of mergers, including with Queen Elizabeth College and Chelsea College of Science and Technology (in 1985), the Institute of Psychiatry (in 1997), the United Medical and Dental Schools of Guy's and St Thomas' Hospitals and the Florence Nightingale School of Nursing and Midwifery (in 1998). King's has five campuses: its historic Strand Campus in central London, three other Thames-side campuses (Guy's, St Thomas' and Waterloo) nearby and one in Denmark Hill in south London. It also has a presence in Shrivenham, Oxfordshire, for its professional milita ...
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Nucleic Acid Double Helix
Nucleus ( : nuclei) is a Latin word for the seed inside a fruit. It most often refers to: *Atomic nucleus, the very dense central region of an atom *Cell nucleus, a central organelle of a eukaryotic cell, containing most of the cell's DNA Nucleus may also refer to: Science, technology, and mathematics Astronomy *Active galactic nucleus in astronomy *Comet nucleus, the solid, central part of a comet Biology *Cell nucleus, a central organelle of a eukaryotic cell, containing most of the cell's DNA *Nucleus (neuroanatomy), a cluster of cell bodies of neurons in the central nervous system *Nucleus that forms in the eye in nuclear sclerosis (early cataracts) *''Nucleus'', a scientific journal concerned with the cell nucleus; published by Taylor & Francis *Nucleus, a small colony of honeybees, induced to raise a new queen by the beekeeper Computer systems * Nucleus (operating system), sometimes a synonym for kernel * Nucleus CMS, a weblog system * Nucleus RTOS, a real-time oper ...
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Francis Crick
Francis Harry Compton Crick (8 June 1916 – 28 July 2004) was an English molecular biologist, biophysicist, and neuroscientist. He, James Watson, Rosalind Franklin, and Maurice Wilkins played crucial roles in deciphering the helical structure of the DNA molecule. Crick and Watson's paper in ''Nature'' in 1953 laid the groundwork for understanding DNA structure and functions. Together with Maurice Wilkins, they were jointly awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material". Crick was an important theoretical molecular biologist and played a crucial role in research related to revealing the helical structure of DNA. He is widely known for the use of the term " central dogma" to summarise the idea that once information is transferred from nucleic acids (DNA or RNA) to proteins, it cannot flow back to nucleic acids. In other words ...
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James Watson
James Dewey Watson (born April 6, 1928) is an American molecular biologist, geneticist, and zoologist. In 1953, he co-authored with Francis Crick the academic paper proposing the double helix structure of the DNA molecule. Watson, Crick and Maurice Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material". In subsequent years, it has been recognized that Watson and his colleagues did not properly attribute colleague Rosalind Franklin for her contributions to the discovery of the double helix structure. Watson earned degrees at the University of Chicago ( BS, 1947) and Indiana University (PhD, 1950). Following a post-doctoral year at the University of Copenhagen with Herman Kalckar and Ole Maaløe, Watson worked at the University of Cambridge's Cavendish Laboratory in England, where he first met his future collaborator Franc ...
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Rosalind Franklin
Rosalind Elsie Franklin (25 July 192016 April 1958) was a British chemist and X-ray crystallographer whose work was central to the understanding of the molecular structures of DNA (deoxyribonucleic acid), RNA (ribonucleic acid), viruses, coal, and graphite. Although her works on coal and viruses were appreciated in her lifetime, her contributions to the discovery of the structure of DNA were largely unrecognized during her life, for which she has been variously referred to as the "wronged heroine", the "dark lady of DNA", the "forgotten heroine", a "feminist icon", and the "Sylvia Plath of molecular biology". She graduated in 1941 with a degree in natural sciences from Newnham College, Cambridge, and then enrolled for a PhD in physical chemistry under Ronald George Wreyford Norrish, the 1920 Chair of Physical Chemistry at the University of Cambridge. Disappointed by Norrish's lack of enthusiasm, she took up a research position under the British Coal Utilisation Research Ass ...
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Photo 51
' ''Photo 51'' is an X-ray based fiber diffraction image of a paracrystalline gel composed of DNA fiber taken by Raymond Gosling, a graduate student working under the supervision of Rosalind Franklin in May 1952 at King's College London, while working in Sir John Randall's group. The image was tagged "photo 51" because it was the 51st diffraction photograph that Franklin and Gosling had taken. It was critical evidence in identifying the structure of DNA. Use in discovering structure of DNA According to Raymond Gosling's later account, although photo 51 was an exceptionally clear diffraction pattern of the "B" form of DNA, Franklin was more interested in solving the diffraction pattern of the "A" form of DNA, so she put Gosling's photo 51 to the side. When it had been decided that Franklin would leave King's College, she suggested that Gosling show the photograph to Maurice Wilkins (who would become Gosling's advisor after Franklin left). A few days later, Wilkins showed the ...
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X-ray
An X-ray, or, much less commonly, X-radiation, is a penetrating form of high-energy electromagnetic radiation. Most X-rays have a wavelength ranging from 10  picometers to 10  nanometers, corresponding to frequencies in the range 30  petahertz to 30  exahertz ( to ) and energies in the range 145  eV to 124 keV. X-ray wavelengths are shorter than those of UV rays and typically longer than those of gamma rays. In many languages, X-radiation is referred to as Röntgen radiation, after the German scientist Wilhelm Conrad Röntgen, who discovered it on November 8, 1895. He named it ''X-radiation'' to signify an unknown type of radiation.Novelline, Robert (1997). ''Squire's Fundamentals of Radiology''. Harvard University Press. 5th edition. . Spellings of ''X-ray(s)'' in English include the variants ''x-ray(s)'', ''xray(s)'', and ''X ray(s)''. The most familiar use of X-rays is checking for fractures (broken bones), but X-rays are also used in other ways. ...
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Maurice Wilkins
Maurice Hugh Frederick Wilkins (15 December 1916 – 5 October 2004) was a New Zealand-born British biophysicist and Nobel laureate whose research spanned multiple areas of physics and biophysics, contributing to the scientific understanding of phosphorescence, isotope separation, optical microscopy and X-ray diffraction, and to the development of radar. He is best known for his work at King's College London on the structure of DNA. Wilkins' work on DNA falls into two distinct phases. The first was in 1948–1950, when his initial studies produced the first clear X-ray images of DNA, which he presented at a conference in Naples in 1951 attended by James Watson. During the second phase, 1951–52, Wilkins produced clear "B form" "X" shaped images from squid sperm, images he sent to James Watson and Francis Crick, causing Watson to write "Wilkins... has obtained extremely excellent X-ray diffraction photographs" f DNA In 1953, Wilkins' group coordinator Sir John Randall instru ...
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Calf (animal)
A calf ( : calves) is a young domestic cow or bull. Calves are reared to become adult cattle or are slaughtered for their meat, called veal, and hide. The term ''calf'' is also used for some other species. See "Other animals" below. Terminology "Calf" is the term used from birth to weaning, when it becomes known as a ''weaner'' or ''weaner calf'', though in some areas the term "calf" may be used until the animal is a yearling. The birth of a calf is known as ''calving''. A calf that has lost its mother is an orphan calf, also known as a ''poddy'' or ''poddy-calf'' in British. ''Bobby calves'' are young calves which are to be slaughtered for human consumption. A ''vealer'' is a calf weighing less than about which is at about eight to nine months of age. A young female calf from birth until she has had a calf of her own is called a ''heifer'' (). In the American Old West, a motherless or small, runty calf was sometimes referred to as a dodie. The term "calf" is also used for ...
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