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Reverse Pharmacology
In the field of drug discovery, reverse pharmacology also known as target-based drug discovery (TDD), a hypothesis is first made that modulation of the activity of a specific protein target thought to be disease modifying will have beneficial therapeutic effects. Screening of chemical libraries of small molecules is then used to identify compounds that bind with high affinity to the target. The hits from these screens are then used as starting points for drug discovery. This method became popular after the sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins. This method is the most widely used in drug discovery today. Differently than the classical (forward) pharmacology, with the reverse pharmacology approach ''in vivo'' efficacy of identified active (lead) compounds is usually performed in the final drug discovery stages. See also * Classical pharmacology * Reverse vaccinology Reverse vaccinology is an imp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forward And Reverse Pharmacology
Forward is a relative direction, the opposite of backward. Forward may also refer to: People * Forward (surname) Sports * Forward (association football) * Forward (basketball), including: ** Point forward ** Power forward (basketball) ** Small forward * Forward (ice hockey) ** Power forward (ice hockey) * In rugby football: ** Forwards (rugby league), in rugby league football ** Forwards (rugby union), in rugby union football * Forward Sports, a Pakistan sportswear brand * BK Forward, a Swedish club for association football and bandy Politics * Avante (political party) (Portuguese for ''forward''), a political party in Brazil * Forward (Belgium), a political party in Belgium * Forward (Denmark), a political party in Denmark * Forward (Greenland), a political party in Greenland * Forward Party (United States), a centrist American political party * Kadima (Hebrew for ''forward''), a political party in Israel * La République En Marche! (sometimes translated as ''Forward! ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
