|
Roger Guillemin
Roger Charles Louis Guillemin (; January 11, 1924 – February 21, 2024) was a French-American neuroscientist. He received the National Medal of Science in 1976, and the Nobel Prize in Physiology or Medicine, Nobel Prize for Medicine in 1977 for his work on neurohormones, sharing the prize that year with Andrew Schally and Rosalyn Sussman Yalow. Biography Guillemin was born in Dijon, France. After secondary studies at the Lycée Carnot in Dijon, he began his medical studies at the University of Dijon in 1943. He completed his medical studies at the University of Lyon and received Doctor of Medicine, MD degree in 1949. He worked as a doctor in a small village in Burgundy, and went to Montreal, Quebec, Canada, to work with Hans Selye at the Institute of Experimental Medicine and Surgery at the Université de Montréal where he received a Ph.D. in 1953. In 1965, he became a United States nationality law, naturalized citizen of the United States. In 1954, Guillemin observed that pit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dijon
Dijon (, ; ; in Burgundian language (Oïl), Burgundian: ''Digion'') is a city in and the Prefectures in France, prefecture of the Côte-d'Or Departments of France, department and of the Bourgogne-Franche-Comté Regions of France, region in eastern France. the Communes of France, commune had a population of 156,920. The earliest archaeological finds within the city limits of Dijon date to the Neolithic Period (geology), period. Dijon later became a Roman Empire, Roman settlement named ''Divio'', located on the road between Lyon and Paris. The province was home to the Duke of Burgundy, Dukes of Burgundy from the early 11th until the late 15th centuries, and Dijon became a place of tremendous wealth and power, one of the great European centres of art, learning, and science. The city has retained varied architectural styles from many of the main periods of the past millennium, including Capetian, Gothic architecture, Gothic, and Renaissance architecture, Renaissance. Many still-i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Dijon
A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law and notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens, Hilde''A History of the University in Europe: Volume 1, Universities in the Midd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salk Institute For Biological Studies
The Salk Institute for Biological Studies is a scientific research institute in the La Jolla community of San Diego, California. The independent, non-profit institute was founded in 1960 by Jonas Salk, the developer of the polio vaccine; among the founding consultants were Jacob Bronowski and Francis Crick. Construction of the research facilities began in spring of 1962. The Salk Institute consistently ranks among the top institutions in the US in terms of research output and quality in the life sciences. As of October 2020, the Salk Institute employs 850 researchers in 60 research groups and focuses its research in three areas: molecular biology and genetics; neurosciences; and plant biology. Research topics include aging, cancer, diabetes, birth defects, Alzheimer's disease, Parkinson's disease, AIDS, and the neurobiology of American Sign Language. March of Dimes provided the initial funding and continues to support the institute. Research is funded by a variety of public sour ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gonadotropin-releasing Hormone
Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. GnRH is inhibited by testosterone. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis. Structure The identity of GnRH was clarified by the 1977 Nobel Laureates Roger Guillemin and Andrew V. Schally: pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 As is standard for peptide representation, the sequence is given from amino terminus to carboxyl terminus; also standard is omission of the designation of chirality, with assumption that all amino acids are in their L- form. The abbreviations are the standard abbreviations for the corresponding proteinogenic amino acids, except for ''pyroGlu'', whic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyrotropin-releasing Hormone
Thyrotropin-releasing hormone (TRH) is a hypophysiotropic hormone produced by neurons in the hypothalamus that stimulates the release of thyroid-stimulating hormone (TSH) as well as prolactin from the anterior pituitary. TRH has been used clinically in diagnosis of hyperthyroidism, and for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans. Its pharmaceutical form is called protirelin ( INN) (). Physiology Synthesis and release TRH is synthesized within parvocellular neurons of the paraventricular nucleus of the hypothalamus. It is translated as a 242-amino acid precursor polypeptide that contains 6 copies of the sequence -Gln-His-Pro-Gly-, with both ends of the sequence flanked by Lys-Arg or Arg-Arg sequences. To produce the mature form, a series of enzymes are required. First, a protease cleaves to the C-terminal side of the flanking Lys-Arg or Arg-Arg. Second, a carboxypeptidase removes the Lys/Arg residues leaving Gly a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyroid Gland
The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans, it is a butterfly-shaped gland located in the neck below the Adam's apple. It consists of two connected lobes. The lower two thirds of the lobes are connected by a thin band of tissue called the isthmus (: isthmi). Microscopically, the functional unit of the thyroid gland is the spherical thyroid follicle, lined with follicular cells (thyrocytes), and occasional parafollicular cells that surround a lumen containing colloid. The thyroid gland secretes three hormones: the two thyroid hormones triiodothyronine (T3) and thyroxine (T4)and a peptide hormone, calcitonin. The thyroid hormones influence the metabolic rate and protein synthesis and growth and development in children. Calcitonin plays a role in calcium homeostasis. Secretion of the two thyroid hormones is regulated by thyroid-stimulating hormone (TSH), which is secreted from the anterior pituitary gland. TSH is regulated by th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyrotropin-releasing Factor
Thyrotropin-releasing hormone (TRH) is a hypophysiotropic hormone produced by neurons in the hypothalamus that stimulates the release of thyroid-stimulating hormone (TSH) as well as prolactin from the anterior pituitary. TRH has been used clinically in diagnosis of hyperthyroidism, and for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans. Its pharmaceutical form is called protirelin (INN) (). Physiology Synthesis and release TRH is synthesized within parvocellular neurons of the paraventricular nucleus of the hypothalamus. It is translated as a 242-amino acid precursor polypeptide that contains 6 copies of the sequence -Gln-His-Pro-Gly-, with both ends of the sequence flanked by Lys-Arg or Arg-Arg sequences. To produce the mature form, a series of enzymes are required. First, a protease cleaves to the C-terminal side of the flanking Lys-Arg or Arg-Arg. Second, a carboxypeptidase removes the Lys/Arg residues leaving Gly as the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roger Burgus
Roger is a masculine given name, and a surname. The given name is derived from the Old French personal names ' and '. These names are of Germanic languages">Germanic origin, derived from the elements ', ''χrōþi'' ("fame", "renown", "honour") and ', ' ("spear", "lance") (Hrōþigēraz). The name was introduced into England by the Normans. In Normandy, the Franks, Frankish name had been reinforced by the Old Norse cognate '. The name introduced into England replaced the Old English cognate '. ''Roger'' became a very common given name during the Middle Ages. A variant form of the given name ''Roger'' that is closer to the name's origin is '' Rodger''. Slang and other uses From up to , Roger was slang for the word "penis". In ''Under Milk Wood'', Dylan Thomas writes "jolly, rodgered" suggesting both the sexual double entendre and the pirate term "Jolly Roger". In 19th-century England, Roger was slang for another term, the cloud of toxic green gas that swept through the chlori ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Veterans Affairs Hospital
Veterans' health care in the United States is separated geographically into 19 regions (numbered 1, 2, 4–10, 12 and 15–23)In January 2002, the Veterans Health Administration announced the merger of VISNs 13 and 14 to create a new, combined network, VISN 23''Transition Watch'', Vol. 5, No 3, May 2002, p.3. known as VISNs, or Veterans Integrated Service Networks, into systems within each network headed by medical centers, and hierarchically within each system by division level of care or type. This article lists VA VISN facilities by region, location, and type. VA medical facilities and Vet Centers are run by the Veterans Health Administration of the United States Department of Veterans Affairs. Vet Centers focus on post-war adjustment, counseling and outreach services for veterans and their families. There are currently 170 VA Medical Centers and approximately 1,193 community-based outpatient clinics in the US. Facilities types (level of care types) are listed in the VISN tabl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Houston
Houston ( ) is the List of cities in Texas by population, most populous city in the U.S. state of Texas and in the Southern United States. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the county seat, seat of Harris County, Texas, Harris County, as well as the principal city of the Greater Houston metropolitan area, the fifth-most populous metropolitan statistical area in the United States and the List of Texas metropolitan areas, second-most populous in Texas after Dallas–Fort Worth metroplex, Dallas–Fort Worth. With a population of 2,314,157 in 2023, Houston is the List of United States cities by population, fourth-most populous city in the United States after New York City, Los Angeles, and Chicago, and the List of North American cities by population, sixth-most populous city in North America. Houston is the southeast anchor of the greater megaregion known as the Texas Triangle. Comprising a land area of , Houston is the List of United S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pituitary Cells
The pituitary gland or hypophysis is an endocrine gland in vertebrates. In humans, the pituitary gland is located at the base of the brain, protruding off the bottom of the hypothalamus. The pituitary gland and the hypothalamus control much of the body's endocrine system. It is seated in part of the sella turcica a depression in the sphenoid bone, known as the hypophyseal fossa. The human pituitary gland is oval shaped, about 1 cm in diameter, in weight on average, and about the size of a kidney bean. Digital version. There are two main lobes of the pituitary, an anterior lobe, and a posterior lobe joined and separated by a small intermediate lobe. The anterior lobe (adenohypophysis) is the glandular part that produces and secretes several hormones. The posterior lobe (neurohypophysis) secretes neurohypophysial hormones produced in the hypothalamus. Both lobes have different origins and they are both controlled by the hypothalamus. Hormones secreted from the pituitary gland ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Nationality Law
United States nationality law details the conditions in which a person holds United States nationality. In the United States, nationality is typically obtained through provisions in the U.S. Constitution, various laws, and international agreements. Citizenship is established as a right under the Constitution, not as a privilege, for those born in the United States under its jurisdiction and those who have been "naturalized". While the words ''citizen'' and ''national'' are sometimes used interchangeably, ''national'' is a broader legal term, such that a person can be a ''national'' but not a ''citizen'', while ''citizen'' is reserved to ''nationals'' who have the status of citizenship. Individuals born in any of the 50 U.S. states, the District of Columbia or almost any inhabited territory are United States citizens (and nationals) by birthright. The sole exception is American Samoa, where individuals are typically non-citizen U.S. nationals at birth. Additionally, individu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
