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RGS16
Regulator of G-protein signaling 16 is a protein that in humans is encoded by the ''RGS16'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b .... Function The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. Interactions RGS16 has been shown to interact with GNAQ and GNAI3. References Further reading * * * * * * * * * * * * * * * * * * * * * * * * * {{PDB Gallery, geneid=6004 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GNAQ Guanine nucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the ''GNAQ'' gene. Together with GNA11 (its paralogue), it functions as a Gq alpha subunit. Function Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230). upplied by OMIM Mutations in this gene have been found associated to cases of Sturge–Weber syndrome and port-wine stains. Interacti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] |